Protein profile

KP13_03126

putative transposase

Genome: KpKP13

Gene: AHE47309.1 Structure source: AlphaFold + ColabFold UniProt Q8GEF2
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Amino acids 513
Annotations 3
Features 11
PDB binders 0
Druggability 0.402

Overview

Basic information about this protein and its source genome.

Accession
KP13_03126
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47309.1
Status
annotated
Amino acids
513
Structure source
AlphaFold + ColabFold
GO
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
83.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.402
Structure Q8GEF2
Pocket Pocket 1
P2Rank 0.652
Structure Q8GEF2
Pocket Pocket 1
ColabFold model
FPocket 0.821 · Pocket 35
P2Rank 0.803 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
480 513 MobiDBLite mobidb-lite consensus disorder prediction
404 425 MobiDBLite mobidb-lite consensus disorder prediction
469 489 Coils Coil Coil
33 127 Pfam PF14319 Transposase zinc-binding domain
33 127 InterPro IPR026889 Transposase zinc-binding domain
172 396 Pfam PF04986 Putative transposase
172 396 InterPro IPR007069 Transposase, IS801/IS1294
59 248 PANTHER PTHR37023 TRANSPOSASE
405 425 MobiDBLite mobidb-lite consensus disorder prediction
1 21 MobiDBLite mobidb-lite consensus disorder prediction
30 465 NCBIfam NF033538 IS91 family transposase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_Q8GEF2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03126
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.402

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.66 0.519
2 8.51 0.454
3 4.7 0.206
4 4.62 0.2
5 2.58 0.074