Overview
Basic information about this protein and its source genome.
- Accession
- KP13_03131
- Gene
- AHE47315.1
- Status
- annotated
- Amino acids
- 261
- Structure source
- AlphaFold + ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Human identity (%)
- 0.0
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- DEG identity (%)
- 0.0
- Localization
- Cytoplasmic
- ColabFold pLDDT
- 86.5
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
3- GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
- GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
- GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 101 | 230 | CDD | cd00009 | AAA |
| 242 | 261 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 1 | 253 | PIRSF | PIRSF003073 | DNAC_TnpB_IstB |
| 1 | 253 | InterPro | IPR028350 | DNA replication protein DnaC/insertion sequence IstB-like |
| 65 | 250 | Gene3D | G3DSA:3.40.50.300 | - |
| 65 | 250 | InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| 243 | 261 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 86 | 231 | SUPERFAMILY | SSF52540 | P-loop containing nucleoside triphosphate hydrolases |
| 86 | 231 | InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| 98 | 231 | SMART | SM00382 | AAA_5 |
| 98 | 231 | InterPro | IPR003593 | AAA+ ATPase domain |
| 11 | 245 | Pfam | PF01695 | IstB-like ATP binding protein |
| 11 | 245 | InterPro | IPR002611 | IstB-like ATP-binding domain |
| 11 | 242 | NCBIfam | NF038214 | IS21-like element helper ATPase IstB |
| 11 | 242 | InterPro | IPR047661 | Insertion sequence IS21-like ATPase IstB |
| 15 | 219 | PANTHER | PTHR30050 | CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_Q8GEF0
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_03131
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 12 | 0.681 | ||||||
| 19 | 0.402 | ||||||
| 1 | 0.344 | ||||||
| 21 | 0.241 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 4.04 | 0.161 | ||||||
| 2 | 3.51 | 0.129 | ||||||
| 3 | 1.13 | 0.008 |
Pockets (P2RANK)
Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).
| P2RANK | Sticks | Spheres | Surfaces | Score | Probability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|---|
| 1 | 5.6 | 0.269 | ||||||
| 2 | 3.12 | 0.105 | ||||||
| 3 | 0.96 | 0.005 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
No virtual-screening candidates for this protein.
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.