Protein profile

KP13_05578

putative transposase

Genome: KpKP13

Gene: AHE47318.1 Structure source: AlphaFold + ColabFold UniProt O86259
Export view
Amino acids 340
Annotations 3
Features 8
PDB binders 0
Druggability 0.809

Overview

Basic information about this protein and its source genome.

Accession
KP13_05578
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47318.1
Status
annotated
Amino acids
340
Structure source
AlphaFold + ColabFold
GO
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.809
Structure O86259
Pocket Pocket 19
P2Rank 0.553
Structure O86259
Pocket Pocket 1
ColabFold model
FPocket 0.5 · Pocket 4
P2Rank 0.478 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
2 332 PANTHER PTHR33055 TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1111A
2 332 InterPro IPR047650 Transposase IS110-like
6 149 Pfam PF01548 Transposase
6 149 InterPro IPR002525 Transposase IS110-like, N-terminal
212 286 Pfam PF02371 Transposase IS116/IS110/IS902 family
212 286 InterPro IPR003346 Transposase IS116/IS110/IS902, C-terminal
5 331 NCBIfam NF033542 IS110 family transposase
5 331 InterPro IPR047650 Transposase IS110-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_O86259
AlphaFold — — full sequence — Viewing
ColabFold KP13_05578
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
19 0.809
3 0.201

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.59 0.4
2 1.96 0.041