Protein profile

KP13_04961

hypothetical protein

Genome: KpKP13

Gene: AHE47392.1 Structure source: AlphaFold + ColabFold UniProt A0A218N5G6
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Amino acids 174
Annotations 1
Features 12
PDB binders 0
Druggability 0.745

Overview

Basic information about this protein and its source genome.

Accession
KP13_04961
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47392.1
Status
annotated
Amino acids
174
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
80.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.745
Structure A0A218N5G6
Pocket Pocket 5
P2Rank
Structure A0A218N5G6
Pocket No pockets
ColabFold model
FPocket 0.562 · Pocket 1
P2Rank 0.085 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
15 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
43 174 NCBIfam TIGR02293 putative toxin-antitoxin system antitoxin component, TIGR02293 family
43 174 InterPro IPR011979 Antitoxin Xre
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
23 174 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
121 171 Pfam PF09722 Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain
121 171 InterPro IPR024467 Antitoxin Xre/MbcA/ParS-like, toxin-binding domain
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 116 Pfam PF20432 Antitoxin Xre-like helix-turn-helix domain
58 116 InterPro IPR046847 Antitoxin Xre-like, helix-turn-helix domain
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A218N5G6
AlphaFold — — full sequence — Viewing
ColabFold KP13_04961
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.745