Protein profile

KP13_32069

Stable plasmid inheritance protein

Genome: KpKP13

Gene: AHE47396.1 flmA Structure source: AlphaFold + ColabFold UniProt A0A024HVW6
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Amino acids 52
Annotations 2
Features 12
PDB binders 0
Druggability 0.405

Overview

Basic information about this protein and its source genome.

Accession
KP13_32069
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47396.1 flmA
Status
annotated
Amino acids
52
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
77.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.405
Structure A0A024HVW6
Pocket Pocket 1
P2Rank
Structure A0A024HVW6
Pocket No pockets
ColabFold model
FPocket 0.195 · Pocket 2
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
27 52 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
27 49 PRINTS PR00281 Hok/Gef cell toxic protein family signature
27 49 InterPro IPR000021 Hok/gef cell toxic protein
7 25 PRINTS PR00281 Hok/Gef cell toxic protein family signature
7 25 InterPro IPR000021 Hok/gef cell toxic protein
8 48 Pfam PF01848 Hok/gef family
8 48 InterPro IPR000021 Hok/gef cell toxic protein
6 26 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 31 ProSitePatterns PS00556 Hok/gef family cell toxic proteins signature.
12 31 InterPro IPR018084 Hok/gef cell toxic protein, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A024HVW6
AlphaFold — — full sequence — Viewing
ColabFold KP13_32069
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.405