Protein profile

KP13_01431

Alpha-D-phosphohexomutase N-terminal domain-containing protein

Genome: KpKP13

Gene: AHE47400.1 Structure source: AlphaFold + ColabFold UniProt A0A377ZAG2
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Amino acids 100
Annotations 8
Features 6
PDB binders 0
Druggability 0.424

Overview

Basic information about this protein and its source genome.

Accession
KP13_01431
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47400.1
Status
annotated
Amino acids
100
Structure source
AlphaFold + ColabFold
EC
5.4.2.10
GO
GO:0016868 Catalysis of the transfer of a phosphate group from one position to another within a single molecule. GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008966 Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. GO:0004615 Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
72.84
DEG E-value
8.83e-36
Localization
Cytoplasmic
ColabFold pLDDT
79.75

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.424
Structure A0A377ZAG2
Pocket Pocket 12
P2Rank 0.168
Structure A0A377ZAG2
Pocket Pocket 1
ColabFold model
FPocket 0.334 · Pocket 5
P2Rank 0.238 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 603 / 4744 genomes with a hit
Normalized 0.127

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0016868 Catalysis of the transfer of a phosphate group from one position to another within a single molecule.
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008966 Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
  • GO:0004615 Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
  • GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
  • GO:0006048 The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
2 81 SUPERFAMILY SSF53738 Phosphoglucomutase, first 3 domains
2 81 InterPro IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III
2 83 Gene3D G3DSA:3.40.120.10 -
3 81 PANTHER PTHR42946 PHOSPHOHEXOSE MUTASE
3 81 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
3 81 InterPro IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377ZAG2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01431
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.424

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.29 0.177