Protein profile

KP13_01430

Tryptophanyl-tRNA synthetase

Genome: KpKP13

Gene: AHE47402.1 Structure source: AlphaFold + ColabFold UniProt A0A1J0R015
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Amino acids 82
Annotations 0
Features 5
PDB binders 0
Druggability 0.271

Overview

Basic information about this protein and its source genome.

Accession
KP13_01430
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47402.1
Status
annotated
Amino acids
82
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.19
Human E-value
8.32e-07
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.964
DEG E-value
5.35e-15
Localization
Cytoplasmic
ColabFold pLDDT
92.83

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.271
Structure A0A1J0R015
Pocket Pocket 1
P2Rank
Structure A0A1J0R015
Pocket No pockets
ColabFold model
FPocket 0.872 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 45 Gene3D G3DSA:1.10.240.10 -
3 76 SUPERFAMILY SSF52374 Nucleotidylyl transferase
46 76 Gene3D G3DSA:3.40.50.620 HUPs
46 76 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
1 77 PANTHER PTHR43766 TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1J0R015
AlphaFold — — full sequence — Viewing
ColabFold KP13_01430
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.271