Protein profile

KP13_01429

Ribosomal RNA small subunit methyltransferase H

Genome: KpKP13

Gene: rsmH AHE47403.1 Structure source: AlphaFold + ColabFold UniProt A0A1J0QYY8
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Amino acids 313
Annotations 5
Features 19
PDB binders 0
Druggability 0.527

Overview

Basic information about this protein and its source genome.

Accession
KP13_01429
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rsmH AHE47403.1
Status
annotated
Amino acids
313
Structure source
AlphaFold + ColabFold
EC
2.1.1.199
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071424 Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine. GO:0070475 The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
37.778
Human E-value
4.82e-17
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.923
DEG E-value
1.6799999999999998e-94
Localization
Cytoplasmic
ColabFold pLDDT
95.3

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.527
Structure A0A1J0QYY8
Pocket Pocket 1
P2Rank 0.943
Structure A0A1J0QYY8
Pocket Pocket 1
ColabFold model
FPocket 0.901 · Pocket 1
P2Rank 0.878 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1695 / 4744 genomes with a hit
Normalized 0.357

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0071424 Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine.
  • GO:0070475 The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
5 313 Hamap MF_01007 Ribosomal RNA small subunit methyltransferase H [rsmH].
5 313 InterPro IPR002903 Ribosomal RNA small subunit methyltransferase H
4 312 PANTHER PTHR11265 S-ADENOSYL-METHYLTRANSFERASE MRAW
4 312 InterPro IPR002903 Ribosomal RNA small subunit methyltransferase H
113 219 Gene3D G3DSA:1.10.150.170 Putative methyltransferase TM0872, insert domain
113 219 InterPro IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily
5 311 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
5 311 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
114 216 SUPERFAMILY SSF81799 Putative methyltransferase TM0872, insert domain
114 216 InterPro IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily
1 313 PIRSF PIRSF004486 MraW
1 313 InterPro IPR002903 Ribosomal RNA small subunit methyltransferase H
31 114 CDD cd02440 AdoMet_MTases
2 313 Pfam PF01795 MraW methylase family
2 313 InterPro IPR002903 Ribosomal RNA small subunit methyltransferase H
3 312 NCBIfam TIGR00006 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH
3 312 InterPro IPR002903 Ribosomal RNA small subunit methyltransferase H
4 313 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
4 313 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1J0QYY8
AlphaFold — — full sequence — Viewing
ColabFold KP13_01429
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.527
6 0.204

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.82 0.831
2 3.95 0.156