Protein profile

KP13_32071

resolvase

Genome: KpKP13

Gene: AHE47409.1 Structure source: AlphaFold + ColabFold UniProt A0A0N8M6Y3
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Amino acids 245
Annotations 4
Features 18
PDB binders 0
Druggability 0.835

Overview

Basic information about this protein and its source genome.

Accession
KP13_32071
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47409.1
Status
annotated
Amino acids
245
Structure source
AlphaFold + ColabFold
GO
GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
83.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.835
Structure A0A0N8M6Y3
Pocket Pocket 1
P2Rank 0.194
Structure A0A0N8M6Y3
Pocket Pocket 1
ColabFold model
FPocket 0.364 · Pocket 6
P2Rank 0.033 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
71 83 ProSitePatterns PS00398 Site-specific recombinases signature 2.
71 83 InterPro IPR006118 Recombinase, conserved site
15 166 Pfam PF00239 Resolvase, N terminal domain
15 166 InterPro IPR006119 Resolvase, N-terminal catalytic domain
12 156 ProSiteProfiles PS51736 Resolvase/invertase-type recombinase catalytic domain profile.
12 156 InterPro IPR006119 Resolvase, N-terminal catalytic domain
11 176 Gene3D G3DSA:3.40.50.1390 -
11 176 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
143 163 Coils Coil Coil
11 166 SUPERFAMILY SSF53041 Resolvase-like
11 166 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
13 166 SMART SM00857 resolvase_6
13 166 InterPro IPR006119 Resolvase, N-terminal catalytic domain
16 24 ProSitePatterns PS00397 Site-specific recombinases active site.
16 24 InterPro IPR006118 Recombinase, conserved site
173 209 Pfam PF02796 Helix-turn-helix domain of resolvase
173 209 InterPro IPR006120 Resolvase, HTH domain
15 171 PANTHER PTHR30461 DNA-INVERTASE FROM LAMBDOID PROPHAGE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0N8M6Y3
AlphaFold — — full sequence — Viewing
ColabFold KP13_32071
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.835

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.26 0.056
2 0.6 0.0
3 0.6 0.0