Protein profile

KP13_32072

resolvase resD

Genome: KpKP13

Gene: AHE47419.1 Structure source: AlphaFold + ColabFold UniProt A0A246R2I0
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Amino acids 246
Annotations 3
Features 10
PDB binders 0
Druggability 0.982

Overview

Basic information about this protein and its source genome.

Accession
KP13_32072
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47419.1
Status
annotated
Amino acids
246
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
82.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.982
Structure A0A246R2I0
Pocket Pocket 1
P2Rank 0.65
Structure A0A246R2I0
Pocket Pocket 1
ColabFold model
FPocket 0.568 · Pocket 9
P2Rank 0.413 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 29 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 245 PIRSF PIRSF004576 Resolvase_Rsv
1 245 InterPro IPR016423 Resolvase, Rsv
40 232 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
40 232 InterPro IPR013762 Integrase-like, catalytic domain superfamily
47 224 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
47 224 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
43 232 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
43 232 InterPro IPR002104 Integrase, catalytic domain
46 223 Pfam PF00589 Phage integrase family
46 223 InterPro IPR002104 Integrase, catalytic domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A246R2I0
AlphaFold — — full sequence — Viewing
ColabFold KP13_32072
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.982
5 0.292
18 0.273
3 0.219

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.3 0.249
2 3.66 0.138
3 3.04 0.1