Protein profile

KP13_01395

Protein mucA

Genome: KpKP13

Gene: mucA AHE47435.1 Structure source: AlphaFold + ColabFold UniProt G9I9A4
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Amino acids 144
Annotations 9
Features 14
PDB binders 0
Druggability 0.689

Overview

Basic information about this protein and its source genome.

Accession
KP13_01395
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mucA AHE47435.1
Status
annotated
Amino acids
144
Structure source
AlphaFold + ColabFold
EC
3.4.21.88 2.7.7.7 3.4.21.-
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0009432 An error-prone process for repairing damaged microbial DNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
80.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.689
Structure G9I9A4
Pocket Pocket 10
P2Rank 0.011
Structure G9I9A4
Pocket Pocket 1
ColabFold model
FPocket 0.408 · Pocket 10
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 60 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 EC 6 GO

Enzyme Commission (EC)

3

Gene Ontology (GO)

6
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
  • GO:0009432 An error-prone process for repairing damaged microbial DNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
20 132 Pfam PF00717 Peptidase S24-like
20 132 InterPro IPR015927 Peptidase S24/S26A/S26B/S26C
54 133 CDD cd06529 S24_LexA-like
54 133 InterPro IPR039418 LexA-like
27 138 Gene3D G3DSA:2.10.109.10 Umud Fragment, subunit A
17 136 SUPERFAMILY SSF51306 LexA/Signal peptidase
17 136 InterPro IPR036286 LexA/Signal peptidase-like superfamily
93 105 PRINTS PR00726 Repressor LexA serine protease (S24) family signature
93 105 InterPro IPR006197 Peptidase S24, LexA-like
65 76 PRINTS PR00726 Repressor LexA serine protease (S24) family signature
65 76 InterPro IPR006197 Peptidase S24, LexA-like
54 64 PRINTS PR00726 Repressor LexA serine protease (S24) family signature
54 64 InterPro IPR006197 Peptidase S24, LexA-like
14 136 PANTHER PTHR33516 LEXA REPRESSOR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_G9I9A4
AlphaFold — — full sequence — Viewing
ColabFold KP13_01395
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.689

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.03 0.006