Protein profile

KP13_01393

Plasmid stable inheritance protein

Genome: KpKP13

Gene: pemI AHE47437.1 Structure source: AlphaFold + ColabFold UniProt Q4JEY2
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Amino acids 97
Annotations 2
Features 9
PDB binders 0
Druggability 0.874

Overview

Basic information about this protein and its source genome.

Accession
KP13_01393
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pemI AHE47437.1
Status
annotated
Amino acids
97
Structure source
AlphaFold + ColabFold
GO
GO:0097351 Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
84.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.874
Structure Q4JEY2
Pocket Pocket 3
P2Rank
Structure Q4JEY2
Pocket No pockets
ColabFold model
FPocket 0.927 · Pocket 4
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 25 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0097351 Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
16 61 ProSiteProfiles PS51740 SpoVT-AbrB domain profile.
16 61 InterPro IPR007159 SpoVT-AbrB domain
16 96 PANTHER PTHR40516 ANTITOXIN CHPS-RELATED
16 96 InterPro IPR039052 Antitoxin PemI-like
10 96 Gene3D G3DSA:2.10.260.10 -
19 64 SMART SM00966 SpoVT_AbrB_2_a
19 64 InterPro IPR007159 SpoVT-AbrB domain
14 87 SUPERFAMILY SSF89447 AbrB/MazE/MraZ-like
14 87 InterPro IPR037914 SpoVT-AbrB domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_Q4JEY2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01393
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.874
2 0.352