Protein profile

KP13_01388

Streptomycin 3''-adenylyltransferase

Genome: KpKP13

Gene: aadA AHE47442.1 Structure source: AlphaFold + ColabFold UniProt A0A0M1TH29
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Amino acids 262
Annotations 6
Features 11
PDB binders 3
Druggability 0.284

Overview

Basic information about this protein and its source genome.

Accession
KP13_01388
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
aadA AHE47442.1
Status
annotated
Amino acids
262
Structure source
AlphaFold + ColabFold
EC
2.7.7.47
GO
GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0070566 Catalysis of the transfer of an adenylyl group to an acceptor. GO:0009012 Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H+. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.284
Structure A0A0M1TH29
Pocket Pocket 3
P2Rank 0.906
Structure A0A0M1TH29
Pocket Pocket 1
ColabFold model
FPocket 0.282 · Pocket 1
P2Rank 0.911 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
  • GO:0070566 Catalysis of the transfer of an adenylyl group to an acceptor.
  • GO:0009012 Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H+.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
152 253 Pfam PF13427 Domain of unknown function (DUF4111)
152 253 InterPro IPR025184 Adenylyltransferase AadA, C-terminal domain
28 97 Pfam PF01909 Nucleotidyltransferase domain
28 97 InterPro IPR002934 Polymerase, nucleotidyl transferase domain
8 262 PIRSF PIRSF000819 Streptomycin_3-adenylyltransf
8 262 InterPro IPR024172 Adenylyltransferase AadA/Aad9
12 107 CDD cd05403 NT_KNTase_like
6 98 Gene3D G3DSA:3.30.460.10 Beta Polymerase, domain 2
6 98 InterPro IPR043519 Nucleotidyltransferase superfamily
7 102 SUPERFAMILY SSF81301 Nucleotidyltransferase
7 102 InterPro IPR043519 Nucleotidyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0M1TH29
AlphaFold — — full sequence — Viewing
ColabFold KP13_01388
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.284

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.03 0.813

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

24 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
71R
5LPA
Q8ZPX9 583.6 Da LogP -7.95 TPSA 334.6 3 viol. ✓ Clean [H]/N=C(\N)/N[C@@H]1[C@H]([C@@H]([C@H]([C@@H]([…
SCM
6XXQ
Q07448 332.4 Da LogP -2.93 TPSA 129.5 ✓ Ro5 ✓ Clean C[C@@H]1CC(=O)[C@]2([C@@H](O1)O[C@@H]3[C@H]([C@…
SRY
5LUH
Q8ZPX9 581.6 Da LogP -7.74 TPSA 331.4 3 viol. ✓ Clean [H]/N=C(/N)\N[C@@H]1[C@H]([C@@H]([C@H]([C@@H]([…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.