Protein profile

KP13_04116

Transposon Tn3 resolvase

Genome: KpKP13

Gene: tnpR AHE47444.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZF9
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Amino acids 185
Annotations 3
Features 23
PDB binders 0
Druggability 0.409

Overview

Basic information about this protein and its source genome.

Accession
KP13_04116
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
tnpR AHE47444.1
Status
annotated
Amino acids
185
Structure source
AlphaFold + ColabFold
GO
GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.409
Structure A0A0H3GZF9
Pocket Pocket 2
P2Rank
Structure A0A0H3GZF9
Pocket No pockets
ColabFold model
FPocket 0.164 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
2 137 ProSiteProfiles PS51736 Resolvase/invertase-type recombinase catalytic domain profile.
2 137 InterPro IPR006119 Resolvase, N-terminal catalytic domain
2 144 PANTHER PTHR30461 DNA-INVERTASE FROM LAMBDOID PROPHAGE
141 181 SUPERFAMILY SSF46689 Homeodomain-like
141 181 InterPro IPR009057 Homeobox-like domain superfamily
1 138 SUPERFAMILY SSF53041 Resolvase-like
1 138 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
3 129 CDD cd03768 SR_ResInv
58 70 ProSitePatterns PS00398 Site-specific recombinases signature 2.
58 70 InterPro IPR006118 Recombinase, conserved site
99 138 Gene3D G3DSA:6.10.250.10 -
141 181 Pfam PF02796 Helix-turn-helix domain of resolvase
141 181 InterPro IPR006120 Resolvase, HTH domain
6 14 ProSitePatterns PS00397 Site-specific recombinases active site.
6 14 InterPro IPR006118 Recombinase, conserved site
1 95 FunFam G3DSA:3.40.50.1390:FF:000005 TnpR recombinase
3 139 SMART SM00857 resolvase_6
3 139 InterPro IPR006119 Resolvase, N-terminal catalytic domain
4 137 Pfam PF00239 Resolvase, N terminal domain
4 137 InterPro IPR006119 Resolvase, N-terminal catalytic domain
1 95 Gene3D G3DSA:3.40.50.1390 -
1 95 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
139 183 Gene3D G3DSA:1.10.10.60 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZF9
AlphaFold — — full sequence — Viewing
ColabFold KP13_04116
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.409