Protein profile

KP13_04117

transposase for transposon gamma-delta-like protein

Genome: KpKP13

Gene: AHE47445.1 Structure source: AlphaFold + ColabFold UniProt B7T4V2
Export view
Amino acids 1001
Annotations 3
Features 7
PDB binders 0
Druggability 0.794

Overview

Basic information about this protein and its source genome.

Accession
KP13_04117
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47445.1
Status
annotated
Amino acids
1001
Structure source
AlphaFold + ColabFold
GO
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.794
Structure B7T4V2
Pocket Pocket 100
P2Rank 0.595
Structure B7T4V2
Pocket Pocket 1
ColabFold model
FPocket 0.354 · Pocket 25
P2Rank 0.607 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
5 172 Pfam PF13700 Domain of unknown function (DUF4158)
5 172 InterPro IPR025296 Domain of unknown function DUF4158
997 1001 Coils Coil Coil
586 975 Pfam PF01526 Tn3 transposase DDE domain
586 975 InterPro IPR002513 Tn3 transposase DDE domain
22 978 NCBIfam NF033527 Tn3 family transposase
22 978 InterPro IPR047653 Tn3-like transposase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_B7T4V2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04117
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
100 0.794

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.22 0.376
2 6.9 0.355
3 3.31 0.117
4 3.1 0.104
5 3.05 0.101