Protein profile

KP13_04118

putative methyl-accepting chemotaxis protein

Genome: KpKP13

Gene: AHE47446.1 Structure source: AlphaFold + ColabFold UniProt A0A1Y6M3E6
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Amino acids 423
Annotations 5
Features 32
PDB binders 0
Druggability 0.935

Overview

Basic information about this protein and its source genome.

Accession
KP13_04118
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47446.1
Status
annotated
Amino acids
423
Structure source
AlphaFold + ColabFold
GO
GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
61.463
DEG E-value
1.4900000000000001e-173
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.935
Structure A0A1Y6M3E6
Pocket Pocket 2
P2Rank 0.014
Structure A0A1Y6M3E6
Pocket Pocket 1
ColabFold model
FPocket 0.388 · Pocket 1
P2Rank 0.01 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
92 134 Gene3D G3DSA:1.10.8.500 HAMP domain in histidine kinase
285 314 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
285 314 InterPro IPR004090 Chemotaxis methyl-accepting receptor
256 283 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
256 283 InterPro IPR004090 Chemotaxis methyl-accepting receptor
179 208 PRINTS PR00260 Bacterial chemotaxis sensory transducer signature
179 208 InterPro IPR004090 Chemotaxis methyl-accepting receptor
94 137 CDD cd06225 HAMP
91 143 ProSiteProfiles PS50885 HAMP domain profile.
91 143 InterPro IPR003660 HAMP domain
75 97 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
135 421 Gene3D G3DSA:1.10.287.950 -
91 143 SMART SM00304 HAMP_11
158 419 SMART SM00283 MA_2
158 419 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
113 419 SUPERFAMILY SSF58104 Methyl-accepting chemotaxis protein (MCP) signaling domain
185 384 CDD cd11386 MCP_signal
1 40 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
223 384 Pfam PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain
223 384 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
148 384 ProSiteProfiles PS50111 Bacterial chemotaxis sensory transducers domain profile.
148 384 InterPro IPR004089 Methyl-accepting chemotaxis protein (MCP) signalling domain
64 74 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
92 136 Pfam PF00672 HAMP domain
92 136 InterPro IPR003660 HAMP domain
226 246 Coils Coil Coil
41 63 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
98 423 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
91 420 FunFam G3DSA:1.10.287.950:FF:000001 Methyl-accepting chemotaxis sensory transducer
44 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
64 418 PANTHER PTHR32089 METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
76 98 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1Y6M3E6
AlphaFold — — full sequence — Viewing
ColabFold KP13_04118
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.935
3 0.327
9 0.244