Protein profile

KP13_32076

transposase insD for insertion element IS2

Genome: KpKP13

Gene: AHE47450.1 Structure source: ColabFold
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Amino acids 282
Annotations 2
Features 12
PDB binders 0
Druggability 0.373

Overview

Basic information about this protein and its source genome.

Accession
KP13_32076
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47450.1
Status
annotated
Amino acids
282
Structure source
ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
79.68

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.373
Structure CB_KP13_32076
Pocket Pocket 5
P2Rank 0.411
Structure CB_KP13_32076
Pocket Pocket 1
ColabFold model
FPocket 0.373 · Pocket 5
P2Rank 0.411 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 14 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
99 253 SUPERFAMILY SSF53098 Ribonuclease H-like
99 253 InterPro IPR012337 Ribonuclease H-like superfamily
2 200 PANTHER PTHR37936 TRANSPOSASE INSC FOR INSERTION ELEMENT IS2A-RELATED
99 263 Gene3D G3DSA:3.30.420.10 -
99 263 InterPro IPR036397 Ribonuclease H superfamily
15 249 NCBIfam NF033516 IS3 family transposase
102 205 Pfam PF00665 Integrase core domain
102 205 InterPro IPR001584 Integrase, catalytic core
84 266 ProSiteProfiles PS50994 Integrase catalytic domain profile.
84 266 InterPro IPR001584 Integrase, catalytic core
28 82 Pfam PF13276 HTH-like domain
28 82 InterPro IPR025948 HTH-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_32076
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.373

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.65 0.202
2 3.62 0.135
3 2.3 0.058
4 0.86 0.003