Protein profile

KP13_03942

Polymerase/histidinol phosphatase domain-containing protein

Genome: KpKP13

Gene: AHE47455.1 Structure source: AlphaFold + ColabFold UniProt A0AB33ISQ4
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Amino acids 895
Annotations 0
Features 11
PDB binders 0
Druggability 0.707

Overview

Basic information about this protein and its source genome.

Accession
KP13_03942
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47455.1
Status
annotated
Amino acids
895
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.707
Structure A0AB33ISQ4
Pocket Pocket 19
P2Rank 0.503
Structure A0AB33ISQ4
Pocket Pocket 1
ColabFold model
FPocket 0.588 · Pocket 13
P2Rank 0.534 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
587 607 Coils Coil Coil
444 464 Coils Coil Coil
5 250 Gene3D G3DSA:3.20.20.140 -
719 858 Gene3D G3DSA:3.40.50.300 -
719 858 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
6 245 SUPERFAMILY SSF89550 PHP domain-like
6 245 InterPro IPR016195 Polymerase/histidinol phosphatase-like
278 852 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
278 852 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
275 646 Gene3D G3DSA:3.40.50.300 -
275 646 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0AB33ISQ4
AlphaFold — — full sequence — Viewing
ColabFold KP13_03942
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
19 0.707

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.56 0.332
2 5.24 0.244
3 3.96 0.157
4 3.9 0.153
5 2.92 0.094