Protein profile

KP13_03956

UvrABC system protein A

Genome: KpKP13

Gene: AHE47468.1 Structure source: AlphaFold + ColabFold UniProt A0A218N2X1
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Amino acids 883
Annotations 7
Features 25
PDB binders 0
Druggability 0.938

Overview

Basic information about this protein and its source genome.

Accession
KP13_03956
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47468.1
Status
annotated
Amino acids
883
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004518 Catalysis of the cleavage of ester linkages within nucleic acids. GO:0008270 Binding to a zinc ion (Zn).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.486
Human E-value
9.37e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
52.632
DEG E-value
1.02e-33
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.938
Structure A0A218N2X1
Pocket Pocket 2
P2Rank 0.99
Structure A0A218N2X1
Pocket Pocket 1
ColabFold model
FPocket 0.825 · Pocket 1
P2Rank 0.927 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 41 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

7 GO

Gene Ontology (GO)

7
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0004518 Catalysis of the cleavage of ester linkages within nucleic acids.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0006281 The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
416 520 Gene3D G3DSA:3.40.50.300 -
416 520 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
169 281 Pfam PF17755 UvrA DNA-binding domain
169 281 InterPro IPR041552 UvrA DNA-binding domain
24 497 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
24 497 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
373 415 Gene3D G3DSA:1.20.1580.10 ABC transporter ATPase like domain
548 799 Pfam PF00005 ABC transporter
548 799 InterPro IPR003439 ABC transporter-like, ATP-binding domain
544 853 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
544 853 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
769 783 ProSitePatterns PS00211 ABC transporters family signature.
769 783 InterPro IPR017871 ABC transporter-like, conserved site
10 160 Gene3D G3DSA:3.40.50.300 -
10 160 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
538 870 ProSiteProfiles PS50893 ATP-binding cassette, ABC transporter-type domain profile.
538 870 InterPro IPR003439 ABC transporter-like, ATP-binding domain
164 287 Gene3D G3DSA:1.10.8.280 -
339 359 MobiDBLite mobidb-lite consensus disorder prediction
141 879 PANTHER PTHR43152 UVRABC SYSTEM PROTEIN A
632 769 Gene3D G3DSA:1.20.1580.10 ABC transporter ATPase like domain
415 429 ProSitePatterns PS00211 ABC transporters family signature.
415 429 InterPro IPR017871 ABC transporter-like, conserved site
535 875 Gene3D G3DSA:3.40.50.300 -
535 875 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A218N2X1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03956
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.938
65 0.397
62 0.3

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.01 0.813
2 17.83 0.809
3 9.39 0.504
4 3.24 0.112
5 3.06 0.102