Protein profile

KP13_04127

hypothetical protein

Genome: KpKP13

Gene: AHE47476.1 Structure source: AlphaFold + ColabFold UniProt A0A1J0QZU7
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Amino acids 102
Annotations 2
Features 7
PDB binders 0
Druggability 0.842

Overview

Basic information about this protein and its source genome.

Accession
KP13_04127
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47476.1
Status
annotated
Amino acids
102
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
87.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.842
Structure A0A1J0QZU7
Pocket Pocket 2
P2Rank
Structure A0A1J0QZU7
Pocket No pockets
ColabFold model
FPocket 0.491 · Pocket 4
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
12 102 PANTHER PTHR35401 COPG FAMILY HELIX-TURN-HELIX PROTEIN-RELATED-RELATED
12 102 InterPro IPR014795 Vibrio phage ICP1, Orf50
16 87 SUPERFAMILY SSF47598 Ribbon-helix-helix
16 87 InterPro IPR010985 Ribbon-helix-helix
15 98 Gene3D G3DSA:1.20.5.780 Single helix bin
20 96 Pfam PF08681 Protein of unknown function (DUF1778)
20 96 InterPro IPR014795 Vibrio phage ICP1, Orf50

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1J0QZU7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04127
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.842