Protein profile

KP13_04142

hypothetical protein

Genome: KpKP13

Gene: AHE47492.1 Structure source: AlphaFold + ColabFold UniProt A0A2H5BS14
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Amino acids 352
Annotations 3
Features 8
PDB binders 0
Druggability 0.381

Overview

Basic information about this protein and its source genome.

Accession
KP13_04142
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47492.1
Status
annotated
Amino acids
352
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872 Binding to a metal ion. GO:0016874 Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.381
Structure A0A2H5BS14
Pocket Pocket 2
P2Rank 0.618
Structure A0A2H5BS14
Pocket Pocket 1
ColabFold model
FPocket 0.317 · Pocket 1
P2Rank 0.611 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046872 Binding to a metal ion.
  • GO:0016874 Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
206 329 Pfam PF15632 ATP-grasp in the biosynthetic pathway with Ter operon
1 352 PIRSF PIRSF029120 UCP029120
1 352 InterPro IPR011226 ATP-grasp family
121 313 ProSiteProfiles PS50975 ATP-grasp fold profile.
121 313 InterPro IPR011761 ATP-grasp fold
109 322 SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like
110 342 Gene3D G3DSA:3.30.470.20 -
61 323 PANTHER PTHR43585 FUMIPYRROLE BIOSYNTHESIS PROTEIN C

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2H5BS14
AlphaFold — — full sequence — Viewing
ColabFold KP13_04142
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.381

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.8 0.527
2 6.47 0.327
3 3.62 0.135
4 3.29 0.116
5 2.69 0.08