Protein profile

KP13_04151

Protein cicA

Genome: KpKP13

Gene: AHE47501.1 cicA Structure source: AlphaFold + ColabFold UniProt A0A024HVU2
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Amino acids 215
Annotations 2
Features 10
PDB binders 0
Druggability 0.852

Overview

Basic information about this protein and its source genome.

Accession
KP13_04151
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47501.1 cicA
Status
annotated
Amino acids
215
Structure source
AlphaFold + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
62.019
DEG E-value
8.460000000000001e-97
Localization
Cytoplasmic
ColabFold pLDDT
90.5

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.852
Structure A0A024HVU2
Pocket Pocket 1
P2Rank 0.291
Structure A0A024HVU2
Pocket Pocket 1
ColabFold model
FPocket 0.238 · Pocket 6
P2Rank 0.132 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 32 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
9 201 CDD cd02612 HAD_PGPPase
11 189 Pfam PF12710 haloacid dehalogenase-like hydrolase
21 93 Gene3D G3DSA:1.20.1440.100 -
10 196 Gene3D G3DSA:3.40.50.1000 -
10 196 InterPro IPR023214 HAD superfamily
10 200 NCBIfam TIGR01490 HAD-IB family hydrolase
10 200 InterPro IPR006385 HAD-superfamily hydrolase, subfamily IB, SerB1-like
9 197 SUPERFAMILY SSF56784 HAD-like
9 197 InterPro IPR036412 HAD-like superfamily
9 191 NCBIfam TIGR01488 HAD-IB family phosphatase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A024HVU2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04151
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.852

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.16 0.169
2 2.04 0.045
3 1.41 0.018