Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 2.5.1.7

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EC Number: 2.5.1.7 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_3252 1,4-dihydroxy-2-naphthoate octaprenyltransferase menA AlphaFold + ColabFold
2.5.1.74
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). GO:0046428Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H+ = a 2-demethylmenaquinol + CO2 + diphosphate. +47 total
0.995 Hit 28.6% 1.07e-19
2 VK055_2895 tRNA dimethylallyltransferase miaA AlphaFold + ColabFold
2.5.1.75
GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0052381Catalysis of the reaction: adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate. +14 total
0.939 Hit 40.2% 2.44e-17
3 VK055_1772 quinolinate synthetase complex, A subunit nadA AlphaFold + ColabFold
2.5.1.72
GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. +47 total
0.87 No Hit 0.0% —
4 VK055_2187 6,7-dimethyl-8-ribityllumazine synthase ribH AlphaFold + ColabFold
2.5.1.78
GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). GO:0009349An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine. GO:0000906Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. +14 total
0.681 No Hit 0.0% —
5 VK055_3878 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA AlphaFold + ColabFold
2.5.1.7
GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008760Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. +69 total
0.245 No Hit 0.0% —
Page 1 of 1 · 5 total proteins