Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
326 VK055_0485 monothiol glutaredoxin, Grx4 family grxD AlphaFold DB model + ColabFold model –
GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. +14 total
No map 0.313 Hit 40.6% 1.75e-22
327 VK055_3086 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase purH AlphaFold DB model + ColabFold model –
GO:0003937Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. +36 total
Chokepoint 2 0.709 Hit 60.0% 1.95e-22
328 VK055_0854 glutaminase A glsA AlphaFold DB model + ColabFold model
3.5.1.2
GO:0006541The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. +14 total
Mapped 1 0.895 Hit 45.3% 2.34e-22
329 VK055_3855 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.748 Hit 24.8% 3.31e-22
330 VK055_3736 yheS yheS AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.45 Hit 42.7% 3.32e-22
331 VK055_4699 dihydrodipicolinate synthase dapA Experimental + ColabFold model
4.3.3.7
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0008840Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. +25 total
Chokepoint 1 0.574 Hit 29.2% 3.67e-22
332 VK055_4629 MFS transporter, sugar porter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.873 Hit 34.7% 4.30e-22
333 VK055_4745 pyridoxal kinase AlphaFold DB model + ColabFold model
2.7.1.35
GO:0008478Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. GO:0009443Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
Chokepoint 4 0.034 Hit 29.5% 4.41e-22
334 VK055_2389 degP htrA AlphaFold DB model + ColabFold model
3.4.21.107
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein.
No map 0.346 Hit 47.0% 5.31e-22
335 VK055_1222 ydjC-like family protein Experimental + ColabFold model –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0000272The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
No map 0.809 Hit 29.0% 5.36e-22
336 VK055_2140 ABC transporter family protein AlphaFold DB model + ColabFold model
7.6.2.2
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +58 total
No map 0.71 Hit 54.3% 6.18e-22
337 VK055_0973 methylated-DNA-[]-cysteine S-methyltransferase family protein AlphaFold DB model + ColabFold model
2.1.1.63
GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +36 total
Mapped 2 0.069 Hit 52.4% 1.31e-21
338 VK055_0262 oligopeptide/dipeptide ABC transporter, ATP-binding, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +14 total
No map 0.481 Hit 32.8% 2.25e-21
339 VK055_4141 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein AlphaFold DB model + ColabFold model –
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. +58 total
No map 0.908 Hit 37.0% 2.42e-21
340 VK055_1967 bacterial regulatory, gntR family protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.635 Hit 23.1% 3.34e-21
341 VK055_3402 2-aminoethylphosphonate--pyruvate transaminase phnW AlphaFold DB model + ColabFold model
2.6.1.37
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0047304Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde.
Mapped 1 0.379 Hit 25.6% 3.96e-21
342 VK055_0965 3-oxoadipate CoA-transferase subunit A pcaI AlphaFold DB model + ColabFold model –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
Chokepoint 2 0.178 Hit 48.2% 4.34e-21
343 VK055_3095 uroporphyrinogen decarboxylase hemE AlphaFold DB model + ColabFold model
4.1.1.37
GO:0004853Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. GO:0006779The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Chokepoint 2 0.095 Hit 70.2% 4.41e-21
344 VK055_3013 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +14 total
No map 0.378 Hit 36.4% 4.91e-21
345 VK055_1666 iaaA AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.344 Hit 41.2% 4.93e-21
346 VK055_4724 putative alcohol dehydrogenase in ethanolamine utilization AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion.
No map 0.993 Hit 25.4% 5.42e-21
347 VK055_2339 hydroxyacylglutathione hydrolase gloB AlphaFold DB model + ColabFold model
3.1.2.6
GO:0019243OBSOLETE. The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into pyruvate via the intermediate (R)-S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. GO:0004416Catalysis of the reaction: an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H+. GO:0046872Binding to a metal ion.
Chokepoint 2 0.516 Hit 36.1% 6.45e-21
348 VK055_1980 HAD ATPase, P-type, IC family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005215Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. +1114 total
No map 0.994 Hit 47.7% 7.17e-21
349 VK055_2864 FKBP-type peptidyl-prolyl cis-trans isomerase AlphaFold DB model + ColabFold model
5.2.1.8
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Mapped 2 0.404 Hit 48.2% 9.57e-21
350 VK055_1337 transaldolase tal AlphaFold DB model + ColabFold model
2.2.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004801Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. +25 total
Mapped 1 0.275 Hit 58.2% 1.02e-20
Page of 204 · 5081 total proteins