Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
551 VK055_0433 2OG-Fe(II) oxygenase superfamily protein AlphaFold DB model + ColabFold model –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0046872Binding to a metal ion.
No map 0.947 0.663 No Hit 0.0% —
552 VK055_5018 glycosyl transferases group 1 family protein AlphaFold DB model + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No map 0.946 0.267 No Hit 0.0% —
553 VK055_4794 chorismate synthase aroC AlphaFold DB model + ColabFold model
4.2.3.5
GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0004107Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
Chokepoint 1 0.946 0.319 No Hit 0.0% —
554 VK055_3026 excinuclease ABC subunit A uvrA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009380Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +69 total
No map 0.946 0.839 Hit 32.9% 1.45e-06
555 VK055_2019 aldo/keto reductase family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.946 0.9 Hit 35.5% 5.34e-10
556 VK055_1755 6-phosphogluconolactonase pgl Experimental + ColabFold model –
GO:0017057Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005515Binding to a protein. +14 total
Chokepoint 1 0.946 0.896 No Hit 0.0% —
557 VK055_1660 lacY lactose MFS transporter lacY2 AlphaFold DB model + ColabFold model –
GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.946 0.777 No Hit 0.0% —
558 VK055_1389 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.946 0.801 No Hit 0.0% —
559 VK055_0248 patatin-like phospholipase family protein AlphaFold DB model + ColabFold model –
GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
No map 0.946 0.782 Hit 35.7% 1.86e-23
560 VK055_4869 glycerol-3-phosphate transporter glpT AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015794The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +58 total
No map 0.945 0.564 Hit 29.5% 1.84e-33
561 VK055_4632 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model – – No map 0.945 0.87 No Hit 0.0% —
562 VK055_4357 L-fuculokinase fucK AlphaFold DB model + ColabFold model
2.7.1.51
GO:0008737Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+. GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +36 total
Chokepoint 2 0.945 0.236 Hit 20.6% 3.37e-09
563 VK055_3938 glutathione S-transferase, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.945 0.765 No Hit 0.0% —
564 VK055_3035 tRNA-dihydrouridine synthase A yjbN AlphaFold DB model + ColabFold model
1.3.1.91
GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0017150Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
Mapped 1 0.945 0.416 Hit 30.9% 2.22e-07
565 VK055_1542 tetraacyldisaccharide 4'-kinase lpxK AlphaFold DB model + ColabFold model
2.7.1.130
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0009029Catalysis of the reaction: a lipid A disaccharide + ATP = a lipid IVA + ADP + H+. +25 total
Chokepoint 6 0.945 0.786 No Hit 0.0% —
566 VK055_1346 hypothetical protein AlphaFold DB model + ColabFold model
2.3.1.286
GO:0036055Catalysis of the reaction: N(6)-succinyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-succinyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. GO:0036054Catalysis of the reaction: N(6)-malonyl-L-lysyl-[protein] + NAD+ + H2O = 2''-O-malonyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]. GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. +47 total
No map 0.945 0.84 Hit 45.2% 1.11e-30
567 VK055_4687 beta-glucoside kinase bglK AlphaFold DB model + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
Mapped 1 0.944 0.425 Hit 26.3% 8.50e-16
568 VK055_4141 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein AlphaFold DB model + ColabFold model –
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. +58 total
No map 0.944 0.908 Hit 37.0% 2.42e-21
569 VK055_2797 acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
No map 0.944 0.527 Hit 40.0% 3.29e-10
570 VK055_2172 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.944 0.417 Hit 33.3% 3.01e-09
571 VK055_2033 putative sugar kinase AlphaFold DB model + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008865Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. +14 total
No map 0.944 0.459 Hit 28.9% 4.57e-16
572 VK055_1359 NADH dehydrogenase II AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol. GO:0019646A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.
No map 0.944 0.818 No Hit 0.0% —
573 VK055_0952 apbE family protein AlphaFold DB model + ColabFold model
2.7.1.180
GO:0017013The addition of a flavin group to a protein amino acid. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.944 0.381 No Hit 0.0% —
574 VK055_0838 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.944 0.855 No Hit 0.0% —
575 VK055_0314 acrB/AcrD/AcrF family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.944 0.718 No Hit 0.0% —
Page of 204 · 5081 total proteins