Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
526 VK055_2049 lysine--tRNA ligase lysS AlphaFold DB model + ColabFold model
6.1.1.6
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +912 total
Chokepoint 2 0.948 0.755 Hit 51.2% 2.64e-17
527 VK055_1723 sulfatase family protein AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2.
No map 0.948 0.941 No Hit 0.0% —
528 VK055_1193 anthranilate synthase component I trpE AlphaFold DB model + ColabFold model
4.1.3.27
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0046872Binding to a metal ion. +14 total
Chokepoint 4 0.948 0.663 No Hit 0.0% —
529 VK055_1012 succinylglutamate desuccinylase astE AlphaFold DB model + ColabFold model
3.5.1.96
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0019544OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-glutamate. GO:0008270Binding to a zinc ion (Zn). +25 total
Chokepoint 1 0.948 0.753 No Hit 0.0% —
530 VK055_5048 putrescine importer puuP2 AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.947 0.566 Hit 27.0% 1.57e-08
531 VK055_5028 phosphoglucomutase/phosphomannomutase, C-terminal domain protein manB AlphaFold DB model + ColabFold model
5.4.2.8
GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. GO:0000287Binding to a magnesium (Mg) ion. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
Mapped 3 0.947 0.243 No Hit 0.0% —
532 VK055_4189 urea transporter yut ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071918The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. GO:0015204Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
No map 0.947 0.77 Hit 42.5% 2.90e-08
533 VK055_4164 lysine--tRNA ligase lysS2 AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +58 total
Chokepoint 2 0.947 0.799 Hit 53.8% 2.09e-18
534 VK055_3802 acrB RND-type permease acrB2 AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +58 total
No map 0.947 0.973 No Hit 0.0% —
535 VK055_3633 conserved hypothetical integral membrane family protein AlphaFold DB model + ColabFold model –
GO:1990397OBSOLETE. Any process which produces queuosine from derivatives of it, without de novo synthesis.
No map 0.947 0.987 No Hit 0.0% —
536 VK055_3565 sulfatase family protein AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. +47 total
No map 0.947 0.929 No Hit 0.0% —
537 VK055_3426 acrB RND-type permease acrB3 AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +58 total
No map 0.947 0.772 No Hit 0.0% —
538 VK055_3088 phosphoribosylamine--glycine ligase purD AlphaFold DB model + ColabFold model
6.3.4.13
GO:0004637Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate. GO:0009113The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0046872Binding to a metal ion. +25 total
Chokepoint 1 0.947 0.788 Hit 55.7% 6.44e-86
539 VK055_3051 malE malE AlphaFold DB model + ColabFold model –
GO:0015144Enables the transfer of carbohydrate from one side of a membrane to the other. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +58 total
No map 0.947 0.641 No Hit 0.0% —
540 VK055_2887 adenylosuccinate synthase purA AlphaFold DB model + ColabFold model
6.3.4.4
GO:0005525Binding to GTP, guanosine triphosphate. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0006164The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. +58 total
Chokepoint 1 0.947 0.975 Hit 43.5% 6.13e-09
541 VK055_2769 zinc-binding dehydrogenase family protein AlphaFold DB model + ColabFold model
1.1.1.2
GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +14 total
No map 0.947 0.605 Hit 30.8% 2.72e-07
542 VK055_2537 triphosphoribosyl-dephospho-CoA synthase CitG citG AlphaFold DB model + ColabFold model
2.4.2.52
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046917Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. +25 total
Chokepoint 1 0.947 0.501 No Hit 0.0% —
543 VK055_2215 phosphate regulon sensor kinase PhoR phoR AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004721Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. +1013 total
No map 0.947 0.913 No Hit 0.0% —
544 VK055_1898 carbohydrate kinase, FGGY family AlphaFold DB model + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.947 0.369 Hit 27.0% 5.01e-06
545 VK055_1400 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.947 0.866 Hit 30.9% 2.54e-09
546 VK055_1124 glycosyl hydrolases family 2, sugar binding domain protein AlphaFold DB model + ColabFold model
3.2.1.25
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004567Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. +14 total
No map 0.947 0.653 Hit 22.6% 1.59e-20
547 VK055_1120 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.947 0.591 No Hit 0.0% —
548 VK055_0930 metallocarboxypeptidase mcar-1 AlphaFold DB model + ColabFold model
3.4.17.19
GO:0004181Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008270Binding to a zinc ion (Zn).
No map 0.947 0.214 No Hit 0.0% —
549 VK055_0648 alpha amylase, catalytic domain protein AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016798Catalysis of the hydrolysis of any glycosyl bond.
No map 0.947 0.773 Hit 43.5% 1.52e-11
550 VK055_0512 electron transport complex, RnfABCDGE type, C subunit AlphaFold DB model + ColabFold model
7.-.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. +36 total
No map 0.947 0.81 No Hit 0.0% —
Page of 204 · 5081 total proteins