Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 VK055_5139 nac transcriptional activator Nac transcriptional dual regulator AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.386 No Hit 0.0% —
52 VK055_5136 regulatory protein TetR family AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.791 No Hit 0.0% —
53 VK055_5134 alpha/beta hydrolase family protein AlphaFold DB model + ColabFold model – – No map 0.949 No Hit 0.0% —
54 VK055_5133 polymyxin resistance PmrD family protein AlphaFold DB model + ColabFold model – – No map 0.03 No Hit 0.0% —
55 VK055_5132 AMP nucleosidase amn Experimental + ColabFold model
3.2.2.4
GO:0044209The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. +25 total
Mapped 3 0.712 No Hit 0.0% —
56 VK055_5130 MATE efflux family protein AlphaFold DB model + ColabFold model –
GO:0015297Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +36 total
No map 0.902 No Hit 0.0% —
57 VK055_5129 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.53 No Hit 0.0% —
58 VK055_5127 CP4-like integrase int2 AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.02 No Hit 0.0% —
59 VK055_5126 salicylate synthase ybtS AlphaFold DB model + ColabFold model –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008909Catalysis of the reaction: chorismate = isochorismate. GO:0016833Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. +25 total
Chokepoint 1 0.405 No Hit 0.0% —
60 VK055_5122 bacterial regulatory helix-turn-helix, AraC family protein ybtA AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.92 No Hit 0.0% —
61 VK055_5119 thiazolinyl imide reductase family protein ybtU AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.542 No Hit 0.0% —
62 VK055_5116 tonB-dependent siderophore receptor family protein fyuA AlphaFold DB model + ColabFold model –
GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
No map 0.828 No Hit 0.0% —
63 VK055_5115 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.458 No Hit 0.0% —
64 VK055_5114 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.697 No Hit 0.0% —
65 VK055_5113 hemolysin expression modulating family protein ColabFold model – – No map 0.049 No Hit 0.0% —
66 VK055_5112 istB-like ATP binding family protein ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
No map 0.368 No Hit 0.0% —
67 VK055_5111 putative iS100 ATP-binding protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
No map 0.544 No Hit 0.0% —
68 VK055_5110 integrase core domain protein AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.653 No Hit 0.0% —
69 VK055_5109 antidote-toxin recognition MazE family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.291 No Hit 0.0% —
70 VK055_5108 PIN domain protein AlphaFold DB model + ColabFold model
3.1.-.-
GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000287Binding to a magnesium (Mg) ion. +14 total
No map 0.366 No Hit 0.0% —
71 VK055_5107 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.345 No Hit 0.0% —
72 VK055_5106 hypothetical protein ColabFold model – – No map 0.744 No Hit 0.0% —
73 VK055_5105 tonB-dependent siderophore receptor family protein iroN AlphaFold DB model + ColabFold model –
GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +47 total
No map 0.842 No Hit 0.0% —
74 VK055_5104 hypothetical protein ColabFold model – – No map 0.403 No Hit 0.0% —
75 VK055_5103 Putative UDP-glucoronosyl and UDP-glucosyl transferase iroB AlphaFold DB model + ColabFold model –
GO:0008194Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). GO:0017000The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
No map 0.979 No Hit 0.0% —
Page of 204 · 5081 total proteins