Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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8 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 3.1.-.-

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EC Number: 3.1.-.- ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_4362 5'-3' exonuclease, C-terminal SAM fold family protein AlphaFold + ColabFold
3.1.-.-
GO:0017108Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0033567The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand. +58 total
0.538 No Hit 0.0% —
2 VK055_1847 YbeY ybeY AlphaFold + ColabFold
3.1.-.-
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.493 No Hit 0.0% —
3 VK055_5108 PIN domain protein AlphaFold + ColabFold
3.1.-.-
GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.366 No Hit 0.0% —
4 VK055_2906 oligoribonuclease monomer yjeR AlphaFold + ColabFold
3.1.-.-
GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0003676Binding to a nucleic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.317 Hit 60.0% 4.57e-12
5 VK055_0385 CRISPR-associated endonuclease Cas1 cas1 AlphaFold + ColabFold
3.1.-.-
GO:0051607Reactions triggered in response to the presence of a virus that act to protect the cell or organism. GO:0003676Binding to a nucleic acid. GO:0043571Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. +58 total
0.303 No Hit 0.0% —
6 VK055_4850 ribonuclease Z rnz AlphaFold + ColabFold
3.1.-.-
GO:0016891Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. GO:0042779OBSOLETE. Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. GO:0042781Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. +36 total
0.3 Hit 46.0% 3.45e-08
7 VK055_0018 DNA mismatch endonuclease of the very short patch (VSP) mismatch repair pathway AlphaFold + ColabFold
3.1.-.-
GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.292 No Hit 0.0% —
8 VK055_4792 smr domain protein AlphaFold + ColabFold
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. GO:0019843Binding to a ribosomal RNA. +14 total
0.211 No Hit 0.0% —
Page 1 of 1 · 8 total proteins