Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 VK055_0281 phenylalanine--tRNA ligase, beta subunit pheT AlphaFold DB model + ColabFold model
6.1.1.20
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006432The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
Chokepoint 3 0.821 Hit 22.7% 8.04e-10
52 VK055_0289 putative glutathione peroxidase AlphaFold DB model + ColabFold model
1.11.1.24 1.11.1.9
GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. GO:0140824Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O. +14 total
Mapped 1 0.284 Hit 56.5% 3.37e-17
53 VK055_0290 vitamin B12 import ATP-binding protein BtuD btuD AlphaFold DB model + ColabFold model
7.6.2.8
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015889The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.823 Hit 29.8% 1.69e-06
54 VK055_0292 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.647 Hit 44.4% 2.96e-95
55 VK055_0300 4Fe-4S dicluster domain protein AlphaFold DB model + ColabFold model
1.1.99.39
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +69 total
No map 0.934 Hit 29.6% 3.52e-08
56 VK055_0307 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.329 Hit 36.2% 6.53e-07
57 VK055_0315 L-lactate dehydrogenase lctD AlphaFold DB model + ColabFold model –
GO:0004457Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0006089The chemical reactions and pathways involving lactate, the anion of lactic acid. +47 total
Mapped 1 0.935 Hit 35.7% 4.78e-66
58 VK055_0319 feS assembly scaffold SufA sufA AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.212 Hit 37.7% 9.33e-25
59 VK055_0321 feS assembly ATPase SufC sufC AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.227 Hit 31.0% 2.68e-10
60 VK055_0323 cysteine desulfurase sufS AlphaFold DB model + ColabFold model –
GO:0006534OBSOLETE. The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. +14 total
Chokepoint 22 0.513 Hit 32.1% 5.17e-07
61 VK055_0327 pyruvate kinase pyk2 AlphaFold DB model + ColabFold model
2.7.1.40
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030955Binding to a potassium ion (K+). GO:0004743Catalysis of the reaction: ADP + H+ + phosphoenolpyruvate = ATP + pyruvate. +58 total
Mapped 4 0.505 Hit 56.4% 7.25e-09
62 VK055_0331 xylose isomerase-like TIM barrel family protein AlphaFold DB model + ColabFold model
4.2.1.118
GO:0046565Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. GO:0046279The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. +14 total
No map 0.6 Hit 26.4% 2.18e-07
63 VK055_0332 major Facilitator Superfamily protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.409 Hit 33.0% 2.97e-06
64 VK055_0334 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.407 Hit 32.9% 3.65e-09
65 VK055_0339 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase mhpA AlphaFold DB model + ColabFold model
1.14.13.127
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0019622The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate. GO:0008688Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. +14 total
Chokepoint 1 0.986 Hit 23.2% 6.84e-10
66 VK055_0341 2-hydroxy-6-oxononadienedioate/2-hydroxy-6- oxononatrienedioate hydrolase mhpC AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0042803Binding to an identical protein to form a homodimer. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. +36 total
Chokepoint 1 0.68 Hit 29.4% 2.92e-07
67 VK055_0344 4-hydroxy-2-oxovalerate aldolase dmpG AlphaFold DB model + ColabFold model
4.1.3.39
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. GO:0008701Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. +58 total
Mapped 1 0.032 Hit 26.5% 3.24e-07
68 VK055_0345 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.896 Hit 35.7% 9.63e-08
69 VK055_0346 multi-copper polyphenol oxidoreductase laccase family protein AlphaFold DB model + ColabFold model – – No map 0.596 Hit 29.4% 2.30e-08
70 VK055_0351 acyl-CoA dehydrogenase, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
No map 0.817 Hit 25.1% 9.19e-15
71 VK055_0355 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.401 Hit 35.6% 6.76e-06
72 VK055_0358 putative siderophore transport system ATP-binding protein yusV AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.201 Hit 34.2% 6.90e-07
73 VK055_0363 bacterial extracellular solute-binding, 3 familyprotein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
No map 0.859 Hit 34.0% 1.22e-08
74 VK055_0365 amino acid ABC transporter artP AlphaFold DB model + ColabFold model –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015424Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). +25 total
No map 0.277 Hit 61.1% 1.52e-06
75 VK055_0377 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015697The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
No map 0.529 Hit 38.3% 2.46e-19
Page of 204 · 5081 total proteins