Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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9 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 6.1.1.1

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EC Number: 6.1.1.1 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_03310 Glutaminyl-tRNA synthetase glnS AlphaFold + ColabFold
6.1.1.18
GO:0006425The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +811 total
0.933 Hit 69.7% 2.17e-07
2 KP13_00247 Glycyl-tRNA synthetase beta subunit glyS AlphaFold + ColabFold
6.1.1.14
GO:0004814Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004820Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). +58 total
0.918 No Hit 0.0% —
3 KP13_18595 Methionyl-tRNA synthetase metG AlphaFold + ColabFold
6.1.1.10
GO:0006431The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0000049Binding to a transfer RNA. +69 total
0.836 Hit 42.6% 7.73e-06
4 KP13_01784 Prolyl-tRNA synthetase proS AlphaFold + ColabFold
6.1.1.15
GO:0004827Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +69 total
0.725 Hit 45.6% 6.86e-64
5 KP13_05164 Tyrosyl-tRNA synthetase tyrS AlphaFold + ColabFold
6.1.1.1
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0004831Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+. GO:0006418The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. +69 total
0.419 Hit 42.0% 1.38e-53
6 KP13_03562 Glutamyl-tRNA synthetase gltX AlphaFold + ColabFold
6.1.1.17
GO:0008270Binding to a zinc ion (Zn). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0004818Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). +710 total
0.394 Hit 36.4% 3.23e-65
7 KP13_00246 Glycyl-tRNA synthetase alpha glyQ AlphaFold + ColabFold
6.1.1.14
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004820Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). GO:0006426The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. +36 total
0.376 No Hit 0.0% —
8 KP13_31936 aspartyl-tRNA synthetase aspS AlphaFold + ColabFold
6.1.1.12
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +69 total
0.348 Hit 63.0% 1.23e-06
9 KP13_03589 Cysteinyl-tRNA synthetase cysS AlphaFold + ColabFold
6.1.1.16
GO:0006423The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
0.222 Hit 56.0% 1.66e-25
Page 1 of 1 · 9 total proteins