Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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6 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 6.1.1.2

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EC Number: 6.1.1.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_04176 Asparaginyl-tRNA synthetase asnS AlphaFold + ColabFold
6.1.1.22
GO:0004816Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H+. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0003676Binding to a nucleic acid. +58 total
0.973 Hit 57.1% 7.69e-11
2 KP13_04672 Phenylalanyl-tRNA synthetase beta chain pheT AlphaFold + ColabFold
6.1.1.20
GO:0004826Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). GO:0000049Binding to a transfer RNA. GO:0006432The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +47 total
0.821 Hit 22.7% 5.50e-10
3 KP13_00862 Histidyl-tRNA synthetase hisS AlphaFold + ColabFold
6.1.1.21
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004821Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.645 Hit 25.3% 6.26e-11
4 KP13_04673 phenylalanyl-tRNA synthetase alpha subunit pheS AlphaFold + ColabFold
6.1.1.20
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004826Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). +69 total
0.595 Hit 33.3% 3.03e-10
5 KP13_00709 Tryptophanyl-tRNA synthetase trpS AlphaFold + ColabFold
6.1.1.2
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0006436The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0006418The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. +47 total
0.401 Hit 42.3% 5.96e-87
6 KP13_13547 Tryptophanyl-tRNA synthetase AlphaFold + ColabFold
6.1.1.2
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0006436The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0006418The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. +47 total
0.265 Hit 27.6% 3.93e-26
Page 1 of 1 · 6 total proteins