Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
276 KP13_31886 putative reverse transcriptase retA AlphaFold + ColabFold – – 0.062 No Hit 0.0% —
277 KP13_31884 putative transposase InsK for insertion sequence element IS150 AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.019 No Hit 0.0% —
278 KP13_31883 hypothetical protein ColabFold – – No pocket No Hit 0.0% —
279 KP13_31882 Biotin synthase bioB AlphaFold + ColabFold
2.8.1.6
GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004076Catalysis of the reaction: (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = [sulfur carrier]-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]. +47 total
0.633 No Hit 0.0% —
280 KP13_31881 hypothetical protein AlphaFold + ColabFold – – 0.23 No Hit 0.0% —
281 KP13_31879 HTH-type transcriptional regulator GalR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.628 No Hit 0.0% —
282 KP13_31878 Lipoprotein spr spr AlphaFold + ColabFold
3.4.17.13 3.4.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008234Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0106415GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. +14 total
0.224 No Hit 0.0% —
283 KP13_31877 hypothetical protein Experimental + ColabFold – – 0.634 No Hit 0.0% —
284 KP13_31876 hypothetical protein ColabFold – – 0.028 No Hit 0.0% —
285 KP13_31874 putative cobalt-precorrin-6Y C(5)-methyltransferase cbiE AlphaFold + ColabFold –
GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
0.132 No Hit 0.0% —
286 KP13_31873 Cobalt-precorrin-4 C(11)-methyltransferase cbiF AlphaFold + ColabFold –
GO:0046026Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
0.655 No Hit 0.0% —
287 KP13_31872 putative transposase ColabFold – – 0.287 No Hit 0.0% —
288 KP13_31870 hypothetical protein AlphaFold + ColabFold – – 0.696 No Hit 0.0% —
289 KP13_31867 Glycine betaine-binding periplasmic protein proX AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.858 No Hit 0.0% —
290 KP13_31865 Arabinose 5-phosphate isomerase GutQ gutQ AlphaFold + ColabFold
5.3.1.13
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. +58 total
0.346 No Hit 0.0% —
291 KP13_31864 Carbamoyltransferase hypF hypF AlphaFold + ColabFold
6.2.-.-
GO:0008270Binding to a zinc ion (Zn). GO:0003725Binding to double-stranded RNA. GO:0046872Binding to a metal ion. +58 total
0.677 No Hit 0.0% —
292 KP13_31863 hydrogenase nickel incorporation protein HypB hypB AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0016151Binding to a nickel (Ni) cation. GO:0051604Any process leading to the attainment of the full functional capacity of a protein. +25 total
0.434 No Hit 0.0% —
293 KP13_31860 hypothetical protein AlphaFold + ColabFold – – 0.133 No Hit 0.0% —
294 KP13_31857 hypothetical protein ColabFold – – 0.219 No Hit 0.0% —
295 KP13_31855 GCN5-like N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.212 No Hit 0.0% —
296 KP13_31854 putative dithiobiotin synthetase AlphaFold + ColabFold
6.3.3.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0000287Binding to a magnesium (Mg) ion. +36 total
0.127 No Hit 0.0% —
297 KP13_31853 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
298 KP13_31852 hypothetical protein AlphaFold + ColabFold – – 0.312 No Hit 0.0% —
299 KP13_31851 hypothetical protein AlphaFold + ColabFold – – 0.305 No Hit 0.0% —
300 KP13_31850 hypothetical protein ColabFold – – 0.491 No Hit 0.0% —
Page of 234 · 5842 total proteins