Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
301 KP13_31849 Beta-lactamase SHV 110 Experimental + ColabFold –
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. +14 total
0.996 No Hit 0.0% —
302 KP13_31848 putative RecF protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0000731Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. +14 total
0.331 No Hit 0.0% —
303 KP13_31847 putative acyl-CoA N-acyltransferase Experimental + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.557 No Hit 0.0% —
304 KP13_31844 hypothetical protein AlphaFold + ColabFold – – 0.41 No Hit 0.0% —
305 KP13_31843 hypothetical protein AlphaFold + ColabFold – – 0.551 No Hit 0.0% —
306 KP13_31842 hypothetical protein AlphaFold + ColabFold – – 0.687 No Hit 0.0% —
307 KP13_31841 hypothetical protein AlphaFold + ColabFold – – 0.38 No Hit 0.0% —
308 KP13_31840 hypothetical protein AlphaFold + ColabFold – – 0.344 No Hit 0.0% —
309 KP13_31839 hypothetical protein AlphaFold + ColabFold – – 0.78 No Hit 0.0% —
310 KP13_31838 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.228 No Hit 0.0% —
311 KP13_31835 HTH-type transcriptional regulator AscG AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.783 No Hit 0.0% —
312 KP13_31834 aspartate racemase AlphaFold + ColabFold –
GO:0047661Catalysis of the reaction: an L-amino acid = a D-amino acid. GO:0016855Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. GO:0036361OBSOLETE. Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. +14 total
0.55 No Hit 0.0% —
313 KP13_31832 Sucrose-6-phosphate hydrolase cscA AlphaFold + ColabFold
3.2.1.26
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +25 total
0.304 No Hit 0.0% —
314 KP13_31831 Type 3 fimbrial subunit MrkB mrkB AlphaFold + ColabFold –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.225 No Hit 0.0% —
315 KP13_31830 Type 3 fimbrial subunit MrkA mrkA AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.041 No Hit 0.0% —
316 KP13_31829 hypothetical protein AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
317 KP13_31828 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase murE AlphaFold + ColabFold
6.3.2.13
GO:0008360Any process that modulates the surface configuration of a cell. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +710 total
0.742 No Hit 0.0% —
318 KP13_31827 hypothetical protein AlphaFold + ColabFold – – 0.506 No Hit 0.0% —
319 KP13_31826 UDP-N-acetylmuramate--L-alanine ligase murC AlphaFold + ColabFold
6.3.2.8
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. +69 total
0.874 No Hit 0.0% —
320 KP13_31825 hypothetical protein ColabFold – – 0.482 No Hit 0.0% —
321 KP13_31824 hypothetical protein ColabFold – – 0.784 No Hit 0.0% —
322 KP13_31822 LysR family regulatory protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.618 No Hit 0.0% —
323 KP13_31821 hypothetical protein AlphaFold + ColabFold – – 0.544 No Hit 0.0% —
324 KP13_31817 hypothetical protein ColabFold – – 0.254 No Hit 0.0% —
325 KP13_31816 hypothetical protein ColabFold – – 0.245 No Hit 0.0% —
Page of 234 · 5842 total proteins