Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4751 KP13_13160 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 AlphaFold + ColabFold
2.7.7.24
GO:0045226OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008879Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. +14 total
0.159 Hit 33.7% 6.45e-10
4752 KP13_03819 putative arsenate reductase AlphaFold + ColabFold
1.20.4.1
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
0.159 No Hit 0.0% —
4753 KP13_03596 Outer membrane protein C AlphaFold + ColabFold – – 0.159 No Hit 0.0% —
4754 KP13_01877 hypothetical protein AlphaFold + ColabFold – – 0.159 No Hit 0.0% —
4755 KP13_01849 ATP-dependent RNA helicase hrpB hrpB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0003676Binding to a nucleic acid. +14 total
0.159 Hit 40.8% 1.53e-18
4756 KP13_00434 hypothetical protein AlphaFold + ColabFold – – 0.159 No Hit 0.0% —
4757 KP13_05250 putative carboxymuconolactone decarboxylase AlphaFold + ColabFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
0.158 No Hit 0.0% —
4758 KP13_03707 hypothetical protein AlphaFold + ColabFold –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion.
0.158 No Hit 0.0% —
4759 KP13_02646 plasmid maintenance killer protein AlphaFold + ColabFold – – 0.158 No Hit 0.0% —
4760 KP13_06702 putative transposase AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.157 No Hit 0.0% —
4761 KP13_03041 Molybdopterin synthase catalytic subunit moaE AlphaFold + ColabFold
2.8.1.12
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0030366Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.
0.157 Hit 33.3% 8.42e-19
4762 KP13_02779 2,5-diketo-D-gluconic acid reductase A dkgA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.157 Hit 47.2% 4.62e-12
4763 KP13_02535 hypothetical protein AlphaFold + ColabFold – – 0.157 No Hit 0.0% —
4764 KP13_00166 Guanylate kinase gmk AlphaFold + ColabFold
2.7.4.8
GO:0004385Catalysis of the reaction: ATP + GMP = ADP + GDP. GO:0006163The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.156 Hit 52.2% 1.84e-06
4765 KP13_32380 DNA-binding transcriptional regulator LrhA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.155 No Hit 0.0% —
4766 KP13_05301 putative acyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.155 No Hit 0.0% —
4767 KP13_05255 hypothetical protein AlphaFold + ColabFold – – 0.155 No Hit 0.0% —
4768 KP13_05069 hypothetical protein AlphaFold + ColabFold – – 0.155 No Hit 0.0% —
4769 KP13_04977 Phenylacetate-coenzyme A ligase paaK AlphaFold + ColabFold
6.2.1.30
GO:0047475Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.155 No Hit 0.0% —
4770 KP13_00163 tRNA guanosine-2'-O-methyltransferase trmH AlphaFold + ColabFold
2.1.1.34
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0030488The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
0.155 Hit 25.3% 1.63e-08
4771 KP13_01500 hypothetical protein AlphaFold + ColabFold – – 0.154 No Hit 0.0% —
4772 KP13_05188 putative pentose kinase AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.153 Hit 23.6% 1.46e-20
4773 KP13_03521 hypothetical protein AlphaFold + ColabFold – – 0.153 No Hit 0.0% —
4774 KP13_04836 hypothetical protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
4775 KP13_04475 hypothetical protein AlphaFold + ColabFold – – 0.152 No Hit 0.0% —
Page of 208 · 5192 total proteins