Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 KP13_00801 Uracil-DNA glycosylase ung AlphaFold + ColabFold
3.2.2.27
GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. GO:0004844Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. GO:0016799Catalysis of the hydrolysis of any N-glycosyl bond. +36 total
0.357 Hit 64.8% 1.46e-72
27 KP13_03156 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.418 Hit 64.7% 7.96e-08
28 KP13_03951 S-(hydroxymethyl)glutathione dehydrogenase frmA AlphaFold + ColabFold
1.1.1.284
GO:0051903Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. GO:0008270Binding to a zinc ion (Zn). GO:0006069OBSOLETE. An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. +47 total
0.563 Hit 64.6% 5.40e-28
29 KP13_03279 Succinate dehydrogenase flavoprotein subunit sdhA AlphaFold + ColabFold
1.3.5.1
GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +69 total
0.582 Hit 63.5% 1.69e-120
30 KP13_01634 Arginyl-tRNA synthetase argS Experimental + AlphaFold + ColabFold –
GO:0004814Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
0.198 Hit 63.3% 3.06e-18
31 KP13_02901 Dihydrolipoamide dehydrogenase acoD AlphaFold + ColabFold
1.8.1.4
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. +47 total
0.926 Hit 63.2% 2.81e-16
32 KP13_31936 aspartyl-tRNA synthetase aspS AlphaFold + ColabFold
6.1.1.12
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +69 total
0.348 Hit 63.0% 1.23e-06
33 KP13_02449 Amino acid ABC transporter, permease protein/ATP-binding protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
0.811 Hit 62.9% 8.68e-07
34 KP13_02957 Biotin carboxylase accC AlphaFold + ColabFold
6.3.4.14
GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. GO:0046872Binding to a metal ion. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.564 Hit 62.5% 6.92e-08
35 KP13_02389 CTP synthase pyrG AlphaFold + ColabFold
6.3.4.2
GO:0006241The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. GO:0006221The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0003883Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. +811 total
0.654 Hit 62.4% 2.36e-43
36 KP13_32134 ATP-dependent Clp protease ATP-binding subunit ClpX clpX AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0008270Binding to a zinc ion (Zn). GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. +811 total
0.613 Hit 62.2% 3.12e-07
37 KP13_32048 hypothetical protein ColabFold – – 0.019 Hit 62.2% 4.80e-08
38 KP13_02390 Enolase eno AlphaFold + ColabFold
4.2.1.11
GO:0000015A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. GO:0004634Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. GO:0000287Binding to a magnesium (Mg) ion. +36 total
0.651 Hit 61.6% 4.81e-49
39 KP13_31541 DNA mismatch repair protein mutS mutS AlphaFold + ColabFold –
GO:0140664A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0030983Binding to a double-stranded DNA region containing one or more mismatches. +36 total
0.534 Hit 61.5% 6.97e-10
40 KP13_01463 Peptide chain release factor 1 prfA AlphaFold + ColabFold –
GO:0016149A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. +14 total
0.771 Hit 61.5% 3.41e-45
41 KP13_31914 Fumarate hydratase class II fumC AlphaFold + ColabFold
4.2.1.2
GO:0006106The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0045239Any of the heteromeric enzymes that act in the TCA cycle. +69 total
0.806 Hit 61.4% 6.20e-178
42 KP13_15895 Agmatinase AlphaFold + ColabFold
3.5.3.11
GO:0016813Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. GO:0046872Binding to a metal ion. GO:0008783Catalysis of the reaction: agmatine + H2O = putrescine + urea. +25 total
0.531 Hit 61.4% 5.34e-136
43 KP13_01980 Chaperone protein dnaJ dnaJ AlphaFold + ColabFold –
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0031072Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. GO:0051082Binding to an unfolded protein. +69 total
0.492 Hit 61.3% 4.18e-07
44 KP13_03313 Glucosamine-6-phosphate deaminase AlphaFold + ColabFold
3.5.99.6
GO:0004342Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0006044The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. +58 total
0.562 Hit 61.2% 9.23e-69
45 KP13_05514 amino acid ABC transporter, ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.058 Hit 61.1% 1.27e-06
46 KP13_05329 Glutamine transport ATP-binding protein glnQ AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.277 Hit 61.1% 1.51e-06
47 KP13_04312 Glutamine transport ATP-binding protein glnQ glnQ AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +14 total
0.223 Hit 61.1% 7.30e-07
48 KP13_03328 Glutamate/aspartate transport ATP-binding protein gltL gltL AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.638 Hit 61.1% 1.58e-06
49 KP13_02123 Amino acid ABC superfamily ATP binding cassette transporter, ABC protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.433 Hit 61.1% 6.83e-07
50 KP13_04195 Lipid A export ATP-binding/permease protein msbA msbA AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034040Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). +69 total
0.97 Hit 61.0% 2.54e-24
Page of 234 · 5842 total proteins