Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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9 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 4.2.1.2

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EC Number: 4.2.1.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_05358 Tryptophan synthase beta chain trpB AlphaFold + ColabFold
4.2.1.20
GO:0004834Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. GO:0006568The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. +14 total
0.945 No Hit 0.0% —
2 KP13_31914 Fumarate hydratase class II fumC AlphaFold + ColabFold
4.2.1.2
GO:0006106The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. GO:0045239Any of the heteromeric enzymes that act in the TCA cycle. +69 total
0.806 Hit 61.4% 6.20e-178
3 KP13_02838 glycerol dehydratase medium subunit dhaC Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.803 No Hit 0.0% —
4 KP13_04622 hypothetical protein AlphaFold + ColabFold
4.2.1.2
GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O.
0.721 No Hit 0.0% —
5 KP13_02837 glycerol dehydratase small subunit dhaE Experimental + ColabFold
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
0.695 No Hit 0.0% —
6 KP13_05047 Fumarate hydratase class I, anaerobic fumB AlphaFold + ColabFold
4.2.1.2
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +58 total
0.481 No Hit 0.0% —
7 KP13_02102 Delta-aminolevulinic acid dehydratase hemB AlphaFold + ColabFold
4.2.1.24
GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0004655Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen. GO:0046872Binding to a metal ion. +36 total
0.454 Hit 42.4% 3.93e-76
8 KP13_05015 Fumarate hydratase class I, aerobic fumA AlphaFold + ColabFold
4.2.1.2
GO:0006091The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +58 total
0.412 No Hit 0.0% —
9 KP13_03255 putative fumarate hydratase AlphaFold + ColabFold
4.2.1.2
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +14 total
0.369 No Hit 0.0% —
Page 1 of 1 · 9 total proteins