Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
651 KP13_01028 Erythronate-4-phosphate dehydrogenase pdxB AlphaFold + ColabFold
1.1.1.290
GO:0008615The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0033711Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH. +58 total
0.439 Hit 31.2% 1.40e-11
652 KP13_31837 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.954 Hit 38.5% 1.62e-11
653 KP13_04591 putative epoxide hydrolase protein Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.786 Hit 33.3% 1.63e-11
654 KP13_00799 Thioredoxin-2 trxC AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
0.268 Hit 39.7% 1.68e-11
655 KP13_02552 Iron transport system ATP-binding component SitB sitB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.526 Hit 33.5% 1.69e-11
656 KP13_01960 Dihydrofolate reductase folA AlphaFold + ColabFold
1.5.1.3
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0004146Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. +69 total
0.615 Hit 27.5% 1.86e-11
657 KP13_01947 Ribosomal large subunit pseudouridine synthase A rluA AlphaFold + ColabFold
5.4.99.-
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. +58 total
0.318 Hit 48.1% 1.98e-11
658 KP13_02307 Propanediol utilization B12-related protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008817Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin.
0.658 Hit 45.2% 2.05e-11
659 KP13_01713 putative HAD-superfamily hydrolase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.344 Hit 24.7% 2.06e-11
660 KP13_00587 Superoxide dismutase Mn sodA AlphaFold + ColabFold
1.15.1.1
GO:0004784Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +25 total
0.293 Hit 54.3% 2.20e-11
661 KP13_04279 Ribosomal protein S12 methylthiotransferase RimO rimO AlphaFold + ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0035596Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. +58 total
0.499 Hit 31.7% 2.28e-11
662 KP13_00966 Inner membrane transport protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.797 Hit 24.1% 2.35e-11
663 KP13_01163 NAGC-like transcriptional regulator mlc AlphaFold + ColabFold – – 0.209 Hit 24.7% 2.59e-11
664 KP13_02215 PTR2/POT transporter family protein AlphaFold + ColabFold –
GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +58 total
0.915 Hit 33.3% 2.70e-11
665 KP13_03063 Short-chain dehydrogenases/reductases family protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.974 Hit 39.8% 2.71e-11
666 KP13_11760 3'(2'),5'-bisphosphate nucleotidase cysQ cysQ AlphaFold + ColabFold
3.1.3.7
GO:0046854The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. +47 total
0.559 Hit 30.5% 3.30e-11
667 KP13_03220 hypothetical protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +14 total
0.595 Hit 24.0% 3.38e-11
668 KP13_00255 Major facilitator superfamily protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.932 Hit 24.3% 3.51e-11
669 KP13_01284 Trehalose-6-phosphate hydrolase treC AlphaFold + ColabFold
3.2.1.93
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005993The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose. +25 total
0.575 Hit 40.3% 3.65e-11
670 KP13_04467 Gamma-aminobutyraldehyde dehydrogenase prr AlphaFold + ColabFold –
GO:0019145Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. GO:0009447The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +25 total
0.858 Hit 54.4% 3.74e-11
671 KP13_03390 Glucose/ribitol dehydrogenase family protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.699 Hit 41.5% 4.06e-11
672 KP13_03913 Putative pyrimidine permease rutG rutG AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0006864The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.98 Hit 32.4% 4.20e-11
673 KP13_02271 6-phospho-beta-glucosidase gmuD gmuD AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.482 Hit 29.9% 4.29e-11
674 KP13_02918 putative glycerophosphoryl diester phosphodiesterase AlphaFold + ColabFold –
GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
0.356 Hit 39.4% 4.49e-11
675 KP13_02701 Peptidyl-prolyl cis-trans isomerase C ppiC AlphaFold + ColabFold
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.495 Hit 41.8% 4.54e-11
Page of 234 · 5842 total proteins