Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_32436 Transcriptional repressor protein KorC AlphaFold + ColabFold – – 0.552 No Hit 0.0% —
2 KP13_32405 hypothetical protein AlphaFold + ColabFold – – 0.478 No Hit 0.0% —
3 KP13_32404 hypothetical protein ColabFold – – 0.199 No Hit 0.0% —
4 KP13_32400 hypothetical protein AlphaFold + ColabFold – – 0.026 No Hit 0.0% —
5 KP13_32399 hypothetical protein ColabFold – – 0.169 No Hit 0.0% —
6 KP13_32395 hypothetical protein ColabFold – – No pocket No Hit 0.0% —
7 KP13_32394 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.317 No Hit 0.0% —
8 KP13_32393 hypothetical protein ColabFold – – 0.448 No Hit 0.0% —
9 KP13_32392 hypothetical protein ColabFold – – 0.707 No Hit 0.0% —
10 KP13_32391 hypothetical protein ColabFold – – 0.789 No Hit 0.0% —
11 KP13_32390 hypothetical protein ColabFold – – 0.527 No Hit 0.0% —
12 KP13_32389 hypothetical protein ColabFold – – 0.023 No Hit 0.0% —
13 KP13_32388 hypothetical protein AlphaFold + ColabFold – – 0.713 No Hit 0.0% —
14 KP13_32387 hypothetical protein ColabFold – – 0.127 No Hit 0.0% —
15 KP13_32386 hypothetical protein ColabFold – – 0.66 No Hit 0.0% —
16 KP13_32385 hypothetical protein ColabFold – – 0.485 No Hit 0.0% —
17 KP13_32384 hypothetical protein AlphaFold + ColabFold – – 0.722 No Hit 0.0% —
18 KP13_32383 sulfate permease AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.946 Hit 26.8% 6.92e-06
19 KP13_32382 hypothetical protein ColabFold – – 0.081 No Hit 0.0% —
20 KP13_32381 2Fe-2S ferredoxin-type domain-containing protein AlphaFold + ColabFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
0.215 No Hit 0.0% —
21 KP13_32380 DNA-binding transcriptional regulator LrhA AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.155 No Hit 0.0% —
22 KP13_32378 transketolase 2 tkt2 AlphaFold + ColabFold
2.2.1.1
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004802Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.807 Hit 35.9% 1.23e-16
23 KP13_32376 hypothetical protein ColabFold – – 0.682 No Hit 0.0% —
24 KP13_32375 phi assembly chaperone domain-containing protein ColabFold –
GO:0061077OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
0.606 No Hit 0.0% —
25 KP13_32373 hypothetical protein ColabFold – – 0.278 No Hit 0.0% —
Page of 234 · 5842 total proteins