Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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Applied filters EC Number: 5.6.2.2

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EC Number: 5.6.2.2 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA4964 DNA topoisomerase IV subunit A parC, PA4964 AlphaFold DB model
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009340A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA. +912 total
No map 0.94 Hit 28.0% 1.91e-09
2 PA3168 DNA gyrase subunit A gyrA, PA3168 AlphaFold DB model
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009330Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity. +811 total
No map 0.62 Hit 25.4% 2.93e-14
3 PA0004 DNA gyrase subunit B gyrB, PA0004 Experimental + AlphaFold DB model
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
No map 0.61 Hit 24.0% 2.97e-31
4 PA4967 DNA topoisomerase IV subunit B PA4967, parE AlphaFold DB model
5.6.2.2
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0009340A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
No map 0.6 Hit 25.4% 2.40e-32
Page 1 of 1 · 4 total proteins