Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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Applied filters EC Number: 5.6.2.4

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EC Number: 5.6.2.4 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA4284 exodeoxyribonuclease V subunit beta recB, PA4284 AlphaFold DB model
3.1.11.5 5.6.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009338An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. +1013 total
No map 0.893 No Hit N/A —
2 PA5345 ATP-dependent DNA helicase RecG PA5345, recG AlphaFold DB model
5.6.2.4
GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +1013 total
No map 0.882 Hit 24.5% 2.09e-07
3 PA5296 ATP-dependent DNA helicase Rep PA5296, rep AlphaFold DB model
5.6.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
No map 0.879 No Hit N/A —
4 PA5443 DNA-dependent helicase II recL, mutU, uvrD, PA5443 AlphaFold DB model
5.6.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033202A protein complex that possesses DNA helicase activity. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. +1114 total
No map 0.849 No Hit N/A —
5 PA5050 primosome assembly protein PriA PA5050, priA AlphaFold DB model
5.6.2.4
GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +1114 total
No map 0.595 No Hit N/A —
6 PA3344 ATP-dependent DNA helicase RecQ PA3344, recQ AlphaFold DB model
5.6.2.4
GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +1619 total
No map 0.505 Hit 48.9% 6.46e-07
Page 1 of 1 · 6 total proteins