Overview
Basic information about this protein and its source genome.
- Accession
- PA0361
- Gene
- PA0361
- Status
- annotated
- Amino acids
- 577
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 40.506
- Human E-value
- 5.24e-12
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Periplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
5- GO:0034722 Catalysis of the cleavage of a gamma-linked glutamate bond.
- GO:0036374 Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate.
- GO:0103068 OBSOLETE. Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid.
- GO:0006750 The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
- GO:0006751 The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 27 | 577 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 10 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 1 | 26 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM |
| 25 | 564 | PANTHER | PTHR43199 | GLUTATHIONE HYDROLASE |
| 54 | 561 | Pfam | PF01019 | Gamma-glutamyltranspeptidase |
| 34 | 563 | SUPERFAMILY | SSF56235 | N-terminal nucleophile aminohydrolases (Ntn hydrolases) |
| 34 | 563 | InterPro | IPR029055 | Nucleophile aminohydrolases, N-terminal |
| 1 | 26 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 41 | 559 | NCBIfam | TIGR00066 | gamma-glutamyltransferase |
| 41 | 559 | InterPro | IPR000101 | Gamma-glutamyltranspeptidase |
| 23 | 26 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 251 | 267 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 378 | 396 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 402 | 420 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 466 | 483 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 443 | 458 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 282 | 301 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 135 | 153 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 61 | 86 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 153 | 172 | PRINTS | PR01210 | Gamma-glutamyltranspeptidase signature |
| 267 | 372 | Gene3D | G3DSA:1.10.246.130 | - |
| 267 | 372 | InterPro | IPR043138 | Gamma-glutamyltranspeptidase, large subunit, C-terminal domain |
| 1 | 26 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM |
| 11 | 22 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 378 | 566 | Gene3D | G3DSA:3.60.20.40 | - |
| 378 | 566 | InterPro | IPR043137 | Gamma-glutamyltranspeptidase, small subunit |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA0361
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 3 | 0.811 | ||||||
| 1 | 0.235 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| 4UD | O25743 | 144.1 Da LogP -0.83 TPSA 84.9 | ✓ Ro5 | ✓ Clean |
C1C=NO[C@@H]1[C@@H](C(=O)O)N
|
|
| 6FY | P18956 | 310.2 Da LogP -0.74 TPSA 156.0 | ✓ Ro5 | ✓ Clean |
CC[C@H](C(=O)NCC(=O)O)O[P@H](=O)CC[C@@H](C(=O)O…
|
|
| AVN | A9YTT0 | 178.6 Da LogP -0.26 TPSA 84.9 | ✓ Ro5 | ✓ Clean |
C1[C@H](ON=C1Cl)[C@@H](C(=O)O)N
|
|
| AZS | P18956 | 173.1 Da LogP -1.76 TPSA 126.0 | ✓ Ro5 | Alert |
C([C@@H](C(=O)O)N)OC(=O)C=[N+]=[N-]
|
|
| DON | Q65KZ6 | 173.2 Da LogP -0.22 TPSA 116.6 | ✓ Ro5 | Alert |
C(CC(=O)CN=N)[C@@H](C(=O)O)N
|
|
| GBL | A0A6G6IRK3 | 86.1 Da LogP 0.32 TPSA 26.3 | ✓ Ro5 | ✓ Clean |
C1CC(=O)OC1
|
|
| GGL | P18956 | 147.1 Da LogP -0.74 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
C(CC(=O)O)[C@@H](C(=O)O)N
|
|
| GTB | O25743 | 442.5 Da LogP -0.29 TPSA 202.0 | ✓ Ro5 | ✓ Clean |
c1cc(ccc1CSC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H]…
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC2031112 | 0.824 | 200.2 Da LogP 1.43 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCC(=O)OCCCCO1
|
| ZINC113251999 | 0.778 | 228.3 Da LogP 2.21 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCC(=O)OCCCCCCO1
|
| ZINC34542648 | 0.778 | 228.3 Da LogP 2.21 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCOC(=O)CCCCCO1
|
| ZINC4023310 | 0.778 | 212.3 Da LogP 3.83 TPSA 26.3 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCCCCO1
|
| ZINC4023520 | 0.778 | 240.4 Da LogP 4.61 TPSA 26.3 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCCCCCCO1
|
| ZINC4026026 | 0.778 | 256.3 Da LogP 2.99 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCC(=O)OCCCCO1
|
| ZINC4026253 | 0.778 | 284.4 Da LogP 3.77 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCC(=O)OCCCCCCO1
|
| ZINC4026492 | 0.778 | 270.4 Da LogP 3.38 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCC(=O)OCCCCCO1
|
| ZINC4676827 | 0.778 | 270.4 Da LogP 3.38 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCC(=O)OCCCCCCO1
|
| ZINC33802904 | 0.765 | 344.4 Da LogP 1.29 TPSA 105.2 | ✓ Ro5 | ✓ Clean |
O=C1CCCCC(=O)OCCOC(=O)CCCCC(=O)OCCO1
|
| ZINC35906424 | 0.765 | 344.4 Da LogP 1.29 TPSA 105.2 | ✓ Ro5 | ✓ Clean |
O=C1CCC(=O)OCCCCOC(=O)CCC(=O)OCCCCO1
|
| ZINC4026344 | 0.750 | 254.4 Da LogP 3.79 TPSA 43.4 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCCC(=O)OCCC1
|
| ZINC196715962 | 0.722 | 456.6 Da LogP 4.41 TPSA 105.2 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCC(=O)OCCOC(=O)CCCCCCCCC(=O)OCCO1
|
| ZINC4015272 | 0.722 | 228.3 Da LogP 2.21 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCC(=O)OCCO1
|
| ZINC4024376 | 0.722 | 270.4 Da LogP 3.38 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCCCC(=O)OCCO1
|
| ZINC4026271 | 0.722 | 214.3 Da LogP 1.82 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCC(=O)OCCO1
|
| ZINC4794429 | 0.722 | 256.3 Da LogP 2.99 TPSA 52.6 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCCC(=O)OCCO1
|
| ZINC3870210 | 0.698 | 473.4 Da LogP -0.53 TPSA 245.1 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCC(=O)N[C@@H](CSc1ccc([N+](=O)[O-])cc1…
|
| ZINC2106542 | 0.667 | 245.3 Da LogP 1.99 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCCCCCC(=O)O)C(=O)O
|
| ZINC2106543 | 0.667 | 245.3 Da LogP 1.99 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCCCCCCC(=O)O)C(=O)O
|
| ZINC2108713 | 0.667 | 217.3 Da LogP 1.21 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCCCC(=O)O)C(=O)O
|
| ZINC2108714 | 0.667 | 217.3 Da LogP 1.21 TPSA 100.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCCCCC(=O)O)C(=O)O
|
| ZINC3881672 | 0.667 | 256.4 Da LogP 3.85 TPSA 35.5 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCCOCCCCO1
|
| ZINC4026039 | 0.667 | 256.4 Da LogP 3.85 TPSA 35.5 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCOCCCCCO1
|
| ZINC5189357 | 0.667 | 256.4 Da LogP 3.85 TPSA 35.5 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCOCCCCCCO1
|
| ZINC139862480 | 0.650 | 304.3 Da LogP 0.70 TPSA 80.3 | ✓ Ro5 | ✓ Clean |
O=C1CCCCC(=O)OCCOCCOCCOCCO1
|
| ZINC5188445 | 0.650 | 216.2 Da LogP 0.66 TPSA 61.8 | ✓ Ro5 | ✓ Clean |
O=C1CCCCC(=O)OCCOCCO1
|
| ZINC2242694 | 0.643 | 276.2 Da LogP -1.39 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O
|
| ZINC2547582 | 0.643 | 276.2 Da LogP -1.39 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCC(=O)N[C@H](CCC(=O)O)C(=O)O)C(=O)O
|
| ZINC4096970 | 0.643 | 405.4 Da LogP -2.04 TPSA 233.4 | 1 viol. | ✓ Clean |
N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)O)…
|
| ZINC4545890 | 0.643 | 276.2 Da LogP -1.39 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@H](CCC(=O)N[C@@H](CCC(=O)O)C(=O)O)C(=O)O
|
| ZINC4545891 | 0.643 | 276.2 Da LogP -1.39 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@H](CCC(=O)N[C@H](CCC(=O)O)C(=O)O)C(=O)O
|
| ZINC3055005 | 0.619 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC3055007 | 0.619 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC3055010 | 0.619 | 204.2 Da LogP -0.63 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC4024200 | 0.619 | 300.4 Da LogP 3.00 TPSA 61.8 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCCC(=O)OCCOCCO1
|
| ZINC4863091 | 0.619 | 316.4 Da LogP 2.24 TPSA 71.1 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCC(=O)OCCOCCOCCO1
|
| ZINC18024709 | 0.600 | 269.4 Da LogP 4.05 TPSA 58.9 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCCCC/C(=N\O)CCCO1
|
| ZINC72334032 | 0.600 | 241.3 Da LogP 3.27 TPSA 58.9 | ✓ Ro5 | ✓ Clean |
O=C1CCCCCCCC/C(=N\O)CCCO1
|
| ZINC13537379 | 0.593 | 256.3 Da LogP 1.24 TPSA 106.5 | ✓ Ro5 | ✓ Clean |
N[C@@H](CSCc1ccc([N+](=O)[O-])cc1)C(=O)O
|
| ZINC1530265 | 0.593 | 219.2 Da LogP -0.80 TPSA 126.9 | ✓ Ro5 | ✓ Clean |
N[C@H](CCOC(=O)CCC(=O)O)C(=O)O
|
| ZINC1532858 | 0.593 | 219.2 Da LogP -0.80 TPSA 126.9 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCOC(=O)CCC(=O)O)C(=O)O
|
| ZINC1576202 | 0.593 | 204.2 Da LogP -1.62 TPSA 129.7 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCC(=O)NCC(=O)O)C(=O)O
|
| ZINC1680890 | 0.593 | 256.3 Da LogP 1.24 TPSA 106.5 | ✓ Ro5 | ✓ Clean |
N[C@H](CSCc1ccc([N+](=O)[O-])cc1)C(=O)O
|
| ZINC3995565 | 0.593 | 204.2 Da LogP -1.62 TPSA 129.7 | ✓ Ro5 | ✓ Clean |
N[C@H](CCC(=O)NCC(=O)O)C(=O)O
|
| ZINC1555366 | 0.591 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1555367 | 0.591 | 232.3 Da LogP 0.15 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1720127 | 0.591 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCC[C@H](N)C(=O)O)C(=O)O
|
| ZINC1720128 | 0.591 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@@H](CCCCC[C@@H](N)C(=O)O)C(=O)O
|
| ZINC1720130 | 0.591 | 218.3 Da LogP -0.24 TPSA 126.6 | ✓ Ro5 | ✓ Clean |
N[C@H](CCCCC[C@@H](N)C(=O)O)C(=O)O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.