Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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Applied filters EC Number: 2.3.2.2

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EC Number: 2.3.2.2 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA0361 gamma-glutamyltranspeptidase PA0361 AlphaFold
2.3.2.2 3.4.19.13
GO:0034722Catalysis of the cleavage of a gamma-linked glutamate bond. GO:0036374Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. GO:0103068OBSOLETE. Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. +25 total
0.811 Hit 40.5% 5.24e-12
2 PA2618 arginyl-tRNA--protein transferase PA2618, bpt AlphaFold
2.3.2.29
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004057Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg). GO:0008914Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue. +36 total
0.741 Hit 42.4% 5.66e-18
3 PA1338 gamma-glutamyltranspeptidase PA1338, ggt AlphaFold
3.4.19.13 2.3.2.2
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0034722Catalysis of the cleavage of a gamma-linked glutamate bond. GO:0036374Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. +47 total
0.53 Hit 54.2% 7.04e-22
4 PA4368 hypothetical protein PA4368 AlphaFold
2.3.2.27
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0061630Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. GO:0008270Binding to a zinc ion (Zn). +36 total
0.436 No Hit N/A —
Page 1 of 1 · 4 total proteins