Protein profile

PA1574

hypothetical protein

Genome: NC_002516.2

Gene: ppnP PA1574 Structure source: Experimental + AlphaFold UniProt Q9I3E3
Export view
Amino acids 93
Annotations 8
Features 12
PDB binders 0
Druggability 0.661

Overview

Basic information about this protein and its source genome.

Accession
PA1574
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
ppnP PA1574
Status
annotated
Amino acids
93
Structure source
Experimental + AlphaFold
EC
2.4.2.1 2.4.2.2
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047975 Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine. GO:0004731 Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. GO:0016154 Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. GO:0009032 Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. GO:0004850 Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.661
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MFKVNEYFDGTVKSIAFDMTAGPATIGVMAAGEYEFGTSQLEIMHVVAGALTVKLPGSDEWQEYASGSQFTVPANSKFQLKVAQDTAYLCEYR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 6 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

6
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0047975 Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine.
  • GO:0004731 Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
  • GO:0016154 Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate.
  • GO:0009032 Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.
  • GO:0004850 Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
4 92 CDD cd20296 cupin_PpnP-like
1 93 Hamap MF_01537 Pyrimidine/purine nucleoside phosphorylase [ppnP].
1 93 InterPro IPR009664 Pyrimidine/purine nucleoside phosphorylase
3 92 Pfam PF06865 Pyrimidine/purine nucleoside phosphorylase
3 92 InterPro IPR009664 Pyrimidine/purine nucleoside phosphorylase
2 92 PANTHER PTHR36540 PYRIMIDINE/PURINE NUCLEOSIDE PHOSPHORYLASE
2 92 InterPro IPR009664 Pyrimidine/purine nucleoside phosphorylase
1 93 FunFam G3DSA:2.60.120.10:FF:000016 Pyrimidine/purine nucleoside phosphorylase
1 92 SUPERFAMILY SSF51182 RmlC-like cupins
1 92 InterPro IPR011051 RmlC-like cupin domain superfamily
1 93 Gene3D G3DSA:2.60.120.10 Jelly Rolls
1 93 InterPro IPR014710 RmlC-like jelly roll fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7EYP
X-ray 1.50 Å A,B
100.0% 1-93
PDBe RCSB PDBj File
Viewing
AlphaFold PA1574
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.661
2 0.28

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.47 0.688