Protein profile

PA5204

N-acetylglutamate synthase

Genome: NC_002516.2

Gene: PA5204 argA Structure source: AlphaFold UniProt P22567
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Amino acids 432
Annotations 7
Features 24
PDB binders 3
Druggability 0.927

Overview

Basic information about this protein and its source genome.

Accession
PA5204
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA5204 argA
Status
annotated
Amino acids
432
Structure source
AlphaFold
EC
2.3.1.1
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042802 Binding to an identical protein or proteins. GO:0004042 Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+. GO:0004358 Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. GO:0006526 The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.927
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0042802 Binding to an identical protein or proteins.
  • GO:0004042 Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+.
  • GO:0004358 Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.
  • GO:0006526 The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
234 432 PANTHER PTHR30602 AMINO-ACID ACETYLTRANSFERASE
234 432 InterPro IPR010167 Amino-acid N-acetyltransferase
285 432 Gene3D G3DSA:3.40.630.30 -
4 432 NCBIfam TIGR01890 amino-acid N-acetyltransferase
4 432 InterPro IPR010167 Amino-acid N-acetyltransferase
329 389 CDD cd04301 NAT_SF
3 283 SUPERFAMILY SSF53633 Carbamate kinase-like
3 283 InterPro IPR036393 Acetylglutamate kinase-like superfamily
1 432 Hamap MF_01105 Amino-acid acetyltransferase [argA].
1 432 InterPro IPR010167 Amino-acid N-acetyltransferase
321 398 Pfam PF00583 Acetyltransferase (GNAT) family
321 398 InterPro IPR000182 GNAT domain
25 259 Pfam PF00696 Amino acid kinase family
25 259 InterPro IPR001048 Aspartate/glutamate/uridylate kinase
253 409 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
253 409 InterPro IPR016181 Acyl-CoA N-acyltransferase
2 284 FunFam G3DSA:3.40.1160.10:FF:000005 Amino-acid acetyltransferase
1 432 PIRSF PIRSF000423 ArgA
3 284 Gene3D G3DSA:3.40.1160.10 -
3 284 InterPro IPR036393 Acetylglutamate kinase-like superfamily
286 425 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
286 425 InterPro IPR000182 GNAT domain
3 280 CDD cd04237 AAK_NAGS-ABP
3 280 InterPro IPR033719 N-acetylglutamate synthase, kinase-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA5204
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.616

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MLI
3ZZH
Q01217 102.0 Da LogP -3.12 TPSA 80.3 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(=O)[O-]
NLG
3ZZF
Q01217 189.2 Da LogP -0.56 TPSA 103.7 ✓ Ro5 ✓ Clean CC(=O)N[C@@H](CCC(=O)O)C(=O)O
X2W
4USJ
Q9SCL7 269.1 Da LogP -1.01 TPSA 150.2 ✓ Ro5 ✓ Clean CC(=O)N[C@@H](CCC(=O)OP(=O)(O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.