Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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18 / 5572 proteins

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Applied filters EC Number: 2.3.1.1

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EC Number: 2.3.1.1 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA5204 N-acetylglutamate synthase argA, PA5204 AlphaFold DB model
2.3.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042802Binding to an identical protein or proteins. GO:0004042Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+. +36 total
No map 0.927 No Hit N/A —
2 PA3476 acyl-homoserine-lactone synthase vsmI, rhlI, PA3476 AlphaFold DB model
2.3.1.184
GO:0061579Catalysis of the reaction: a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H+. GO:0120218A quorum sensing process that is modulated by some interaction with a host cell or organism. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
No map 0.893 No Hit N/A —
3 PA3673 glycerol-3-phosphate acyltransferase plsB, PA3673 AlphaFold DB model
2.3.1.15
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004366Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA. GO:0016024The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. +58 total
No map 0.876 Hit 40.0% 4.54e-35
4 PA5016 dihydrolipoamide acetyltransferase aceB, aceF, PA5016 AlphaFold DB model
2.3.1.12
GO:0045254A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. GO:0004742Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA. GO:0006086The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. The combination of the three reactions can be summarized as: pyruvate + coenzyme A + NAD+ -> acetyl-CoA + CO2 + NADH. +25 total
No map 0.843 Hit 34.2% 1.85e-33
5 PA1373 3-oxoacyl-ACP synthase PA1373, fabF2 AlphaFold DB model
2.3.1.179
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +25 total
No map 0.783 Hit 44.8% 8.03e-112
6 PA3644 acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase PA3644, lpxA AlphaFold DB model
2.3.1.129
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008780Catalysis of the reaction: a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]. +47 total
No map 0.752 No Hit N/A —
7 PA3666 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase PA3666, dapD Experimental + AlphaFold DB model
2.3.1.117
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008666Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA. GO:0000287Binding to a magnesium (Mg) ion. +25 total
No map 0.748 No Hit N/A —
8 PA0897 arginine N-succinyltransferase subunit beta aruG, PA0897 AlphaFold DB model
2.3.1.109
GO:0008791Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+. GO:0009015Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. +14 total
No map 0.728 No Hit N/A —
9 PA3454 acyl-CoA thiolase PA3454 Experimental + AlphaFold DB model
2.3.1.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033812Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +47 total
No map 0.709 Hit 45.8% 5.02e-103
10 PA0228 beta-ketoadipyl CoA thiolase pcaF, PA0228 Experimental + AlphaFold DB model
2.3.1.174
GO:0033812Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. +58 total
No map 0.705 Hit 46.3% 2.16e-60
11 PA3589 acetyl-CoA acetyltransferase PA3589 Experimental + AlphaFold DB model
2.3.1.16
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033812Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +47 total
No map 0.697 Hit 46.9% 1.63e-52
12 PA0896 arginine N-succinyltransferase subunit alpha aruF, astA, PA0896 Experimental + AlphaFold DB model
2.3.1.109
GO:0008791Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+. GO:0009015Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. +14 total
No map 0.685 No Hit N/A —
13 PA5174 beta-ketoacyl synthase fabY, PA5174 Experimental + AlphaFold DB model
2.3.1.180
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. +69 total
No map 0.649 Hit 24.5% 1.01e-10
14 PA3646 UDP-3-O-acylglucosamine N-acyltransferase PA3646, lpxD Experimental + AlphaFold DB model
2.3.1.191
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. +47 total
No map 0.649 No Hit N/A —
15 PA1432 acyl-homoserine-lactone synthase PA1432, lasI Experimental + AlphaFold DB model
2.3.1.184
GO:0061579Catalysis of the reaction: a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H+. GO:0009372The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms. GO:0007165The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. +14 total
No map 0.641 No Hit N/A —
16 PA2965 3-oxoacyl-ACP synthase fabF1, PA2965 Experimental + AlphaFold DB model
2.3.1.179
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. GO:0046872Binding to a metal ion. +36 total
No map 0.617 Hit 47.3% 3.52e-120
17 PA3997 lipoate-protein ligase B PA3997, lipB AlphaFold DB model
2.3.1.181
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033819Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]. GO:0009249The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. +14 total
No map 0.609 Hit 43.2% 7.13e-12
18 PA2249 branched-chain alpha-keto acid dehydrogenase complex lipoamide acyltransferase bkdB, PA2249 AlphaFold DB model
2.3.1.168
GO:0043754Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA. In addition to transferring the 2-methylpropanoyl group when acting on the oxoacid corresponding with valine, this activity also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups when acting on the oxo acids corresponding with leucine and isoleucine. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
No map 0.585 Hit 31.3% 1.05e-40
Page 1 of 1 · 18 total proteins