Amino acids
464
Annotations
5
Features
37
PDB binders
6
Druggability
0.635
Overview
Basic information about this protein and its source genome.
- Accession
- PA5263
- Gene
- argH PA5263
- Status
- annotated
- Amino acids
- 464
- Structure source
- AlphaFold
EC
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0004056 Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.
GO:0042450 OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 65.306
- Human E-value
- 5.38e-15
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.635
Sequence
Primary amino-acid sequence viewer.
MSVEKTNQSWGGRFSEPVDAFVARFTASVDFDKRLYRHDIMGSIAHATMLAKVGVLSDAERDAIVDGLQQIQAEIEAGSFDWRVDLEDVHMNIEARLTDRIGVTGKKLHTGRSRNDQVATDIRLWLRDEIDTILAEITRLQEGLLGLAEAEADTIMPGFTHLQTAQPVTFGHHLLAWFEMLGRDYERLVDCRKRVNRMPLGSAALAGTTYPIQREITCQLLGFDAVGGNSLDGVSDRDFAIEFCAAASLAMMHLSRFSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVRGKSGRVFGALTGLLTLMKGQPLAYNKDNQEDKEPLFDAADTLRDSLRAFADMVPAIRPRREIMREAARRGFSTATDLADYLVRKGLPFRDCHEIVGHAVKYGVDSGKDLAEMSLDELRRFSEQIDADVFDVLTLEGSVNARDHIGGTAPNQVRAAVARGRKLLAQR
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
1 EC
4 GO
Enzyme Commission (EC)
1Gene Ontology (GO)
4- GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
- GO:0004056 Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.
- GO:0042450 OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.
- GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
Sequence Features
Domain/signature hits from InterPro and related databases.
37 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 8 | 459 | Hamap | MF_00006 | Argininosuccinate lyase [argH]. |
| 8 | 459 | InterPro | IPR009049 | Argininosuccinate lyase |
| 28 | 127 | FunFam | G3DSA:1.10.275.10:FF:000002 | Argininosuccinate lyase |
| 12 | 306 | Pfam | PF00206 | Lyase |
| 12 | 306 | InterPro | IPR022761 | Fumarate lyase, N-terminal |
| 369 | 437 | Pfam | PF14698 | Argininosuccinate lyase C-terminal |
| 369 | 437 | InterPro | IPR029419 | Argininosuccinate lyase, C-terminal |
| 10 | 458 | NCBIfam | TIGR00838 | argininosuccinate lyase |
| 10 | 458 | InterPro | IPR009049 | Argininosuccinate lyase |
| 28 | 461 | CDD | cd01359 | Argininosuccinate_lyase |
| 28 | 461 | InterPro | IPR009049 | Argininosuccinate lyase |
| 366 | 438 | FunFam | G3DSA:1.10.40.30:FF:000001 | Argininosuccinate lyase |
| 281 | 290 | ProSitePatterns | PS00163 | Fumarate lyases signature. |
| 281 | 290 | InterPro | IPR020557 | Fumarate lyase, conserved site |
| 281 | 297 | PRINTS | PR00149 | Fumarate lyase superfamily signature |
| 281 | 297 | InterPro | IPR000362 | Fumarate lyase family |
| 237 | 264 | PRINTS | PR00149 | Fumarate lyase superfamily signature |
| 237 | 264 | InterPro | IPR000362 | Fumarate lyase family |
| 108 | 126 | PRINTS | PR00149 | Fumarate lyase superfamily signature |
| 108 | 126 | InterPro | IPR000362 | Fumarate lyase family |
| 153 | 171 | PRINTS | PR00149 | Fumarate lyase superfamily signature |
| 153 | 171 | InterPro | IPR000362 | Fumarate lyase family |
| 10 | 461 | SUPERFAMILY | SSF48557 | L-aspartase-like |
| 10 | 461 | InterPro | IPR008948 | L-Aspartase-like |
| 125 | 454 | Gene3D | G3DSA:1.20.200.10 | Fumarase/aspartase (Central domain) |
| 28 | 235 | Gene3D | G3DSA:1.10.275.10 | - |
| 28 | 235 | InterPro | IPR024083 | Fumarase/histidase, N-terminal |
| 107 | 129 | PRINTS | PR00145 | Argininosuccinate lyase family signature |
| 316 | 335 | PRINTS | PR00145 | Argininosuccinate lyase family signature |
| 237 | 261 | PRINTS | PR00145 | Argininosuccinate lyase family signature |
| 148 | 168 | PRINTS | PR00145 | Argininosuccinate lyase family signature |
| 281 | 297 | PRINTS | PR00145 | Argininosuccinate lyase family signature |
| 199 | 215 | PRINTS | PR00145 | Argininosuccinate lyase family signature |
| 366 | 438 | Gene3D | G3DSA:1.10.40.30 | - |
| 231 | 381 | FunFam | G3DSA:1.20.200.10:FF:000015 | argininosuccinate lyase isoform X2 |
| 4 | 462 | PANTHER | PTHR43814 | ARGININOSUCCINATE LYASE |
| 4 | 462 | InterPro | IPR009049 | Argininosuccinate lyase |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA5263
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 2 | 0.588 | ||||||
| 1 | 0.395 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
56 records
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| DTT | Q88N37 | 154.3 Da LogP -0.43 TPSA 40.5 | ✓ Ro5 | ✓ Clean |
C([C@@H]([C@H](CS)O)O)S
|
|
| EKN | Q11KV9 | 176.2 Da LogP -1.54 TPSA 112.7 | ✓ Ro5 | ✓ Clean |
C(CN[C@@H](CC(=O)O)C(=O)O)N
|
|
| EKQ | Q11KV9 | 292.2 Da LogP -1.98 TPSA 173.3 | 1 viol. | ✓ Clean |
C(CN[C@@H](CC(=O)O)C(=O)O)N[C@@H](CC(=O)O)C(=O)O
|
|
| FUM | A0A077EBQ3 | 116.1 Da LogP -0.29 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
C(=C/C(=O)O)\C(=O)O
|
|
| MLI | A0A6L8PR48 | 102.0 Da LogP -3.12 TPSA 80.3 | ✓ Ro5 | ✓ Clean |
C(C(=O)[O-])C(=O)[O-]
|
|
| SIN | Q11KV9 | 118.1 Da LogP -0.06 TPSA 74.6 | ✓ Ro5 | ✓ Clean |
C(CC(=O)O)C(=O)O
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC1532902 | 0.700 | 206.2 Da LogP -0.86 TPSA 132.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CC[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC2018106 | 0.700 | 206.2 Da LogP -0.86 TPSA 132.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CC[C@](O)(CC(=O)O)C(=O)O
|
| ZINC16778862 | 0.667 | 203.2 Da LogP 0.69 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCN[C@@H](CC(=O)O)C(=O)O
|
| ZINC16778864 | 0.667 | 203.2 Da LogP 0.69 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCN[C@H](CC(=O)O)C(=O)O
|
| ZINC3593496 | 0.652 | 206.2 Da LogP -1.16 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
COC(=O)C[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC3593497 | 0.652 | 206.2 Da LogP -1.16 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
COC(=O)C[C@](O)(CC(=O)O)C(=O)O
|
| ZINC5829354 | 0.652 | 268.4 Da LogP -1.07 TPSA 98.7 | 1 viol. | ✓ Clean |
O=C(O)[C@H](CS)NCCN[C@@H](CS)C(=O)O
|
| ZINC100055220 | 0.643 | 245.3 Da LogP 1.86 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCCCCN[C@@H](CC(=O)O)C(=O)O
|
| ZINC100055221 | 0.643 | 245.3 Da LogP 1.86 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCCCCN[C@H](CC(=O)O)C(=O)O
|
| ZINC22011319 | 0.643 | 217.3 Da LogP 1.08 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCCN[C@@H](CC(=O)O)C(=O)O
|
| ZINC22011324 | 0.643 | 217.3 Da LogP 1.08 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCCN[C@H](CC(=O)O)C(=O)O
|
| ZINC2371471449 | 0.643 | 231.3 Da LogP 1.47 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCCCN[C@H](CC(=O)O)C(=O)O
|
| ZINC2371471450 | 0.643 | 231.3 Da LogP 1.47 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CCCCCCCN[C@@H](CC(=O)O)C(=O)O
|
| ZINC14686440 | 0.625 | 436.4 Da LogP -2.64 TPSA 247.9 | 1 viol. | ✓ Clean |
O=C(O)C[C@](O)(CC(=O)NCCCCNC(=O)C[C@@](O)(CC(=O…
|
| ZINC14686442 | 0.625 | 436.4 Da LogP -2.64 TPSA 247.9 | 1 viol. | ✓ Clean |
O=C(O)C[C@@](O)(CC(=O)NCCCCNC(=O)C[C@](O)(CC(=O…
|
| ZINC14686444 | 0.625 | 436.4 Da LogP -2.64 TPSA 247.9 | 1 viol. | ✓ Clean |
O=C(O)C[C@@](O)(CC(=O)NCCCCNC(=O)C[C@@](O)(CC(=…
|
| ZINC22028986 | 0.609 | 232.3 Da LogP -0.11 TPSA 98.7 | ✓ Ro5 | ✓ Clean |
CC[C@@H](NCCN[C@H](CC)C(=O)O)C(=O)O
|
| ZINC22576811 | 0.609 | 232.3 Da LogP -0.11 TPSA 98.7 | ✓ Ro5 | ✓ Clean |
CC[C@H](NCCN[C@@H](CC)C(=O)O)C(=O)O
|
| ZINC22576817 | 0.609 | 232.3 Da LogP -0.11 TPSA 98.7 | ✓ Ro5 | ✓ Clean |
CC[C@H](NCCN[C@H](CC)C(=O)O)C(=O)O
|
| ZINC1709621 | 0.600 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@@H](CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC1709622 | 0.600 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC1709623 | 0.600 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@@H](CC(=O)N[C@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC1709624 | 0.600 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@H](CC(=O)N[C@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC2697495 | 0.581 | 246.3 Da LogP 0.24 TPSA 89.9 | ✓ Ro5 | ✓ Clean |
CCN(CC)CCCN[C@@H](CC(=O)O)C(=O)O
|
| ZINC2697497 | 0.581 | 246.3 Da LogP 0.24 TPSA 89.9 | ✓ Ro5 | ✓ Clean |
CCN(CC)CCCN[C@H](CC(=O)O)C(=O)O
|
| ZINC13398039 | 0.577 | 234.2 Da LogP -0.38 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
CC(C)OC(=O)C[C@](O)(CC(=O)O)C(=O)O
|
| ZINC2528012 | 0.577 | 234.2 Da LogP -0.38 TPSA 121.1 | ✓ Ro5 | ✓ Clean |
CC(C)OC(=O)C[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC22923755 | 0.576 | 349.3 Da LogP -3.22 TPSA 218.1 | 1 viol. | ✓ Clean |
N=C(N)NC[C@@H](O)C[C@H](NCCN[C@@H](CC(=O)O)C(=O…
|
| ZINC22930764 | 0.576 | 349.3 Da LogP -3.22 TPSA 218.1 | 1 viol. | ✓ Clean |
N=C(N)NC[C@H](O)C[C@@H](NCCN[C@@H](CC(=O)O)C(=O…
|
| ZINC1572706 | 0.563 | 260.2 Da LogP -1.05 TPSA 132.8 | ✓ Ro5 | ✓ Clean |
O=C(O)CCC(=O)NCCNC(=O)CCC(=O)O
|
| ZINC146315135 | 0.560 | 204.2 Da LogP 0.86 TPSA 94.8 | ✓ Ro5 | ✓ Clean |
CCCCC[C@@](O)(CC(=O)O)C(=O)O
|
| ZINC146315336 | 0.560 | 204.2 Da LogP 0.86 TPSA 94.8 | ✓ Ro5 | ✓ Clean |
CCCCC[C@](O)(CC(=O)O)C(=O)O
|
| ZINC1575288 | 0.560 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O
|
| ZINC1575289 | 0.560 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O
|
| ZINC1575290 | 0.560 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@@H](CC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)O
|
| ZINC1575291 | 0.560 | 248.2 Da LogP -2.17 TPSA 167.0 | ✓ Ro5 | ✓ Clean |
N[C@H](CC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)O
|
| ZINC5131760 | 0.560 | 237.2 Da LogP -0.94 TPSA 137.9 | ✓ Ro5 | ✓ Clean |
N[C@@H](CS[C@@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC5131761 | 0.560 | 237.2 Da LogP -0.94 TPSA 137.9 | ✓ Ro5 | ✓ Clean |
N[C@H](CS[C@@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC5131922 | 0.560 | 237.2 Da LogP -0.94 TPSA 137.9 | ✓ Ro5 | ✓ Clean |
N[C@@H](CS[C@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC5131923 | 0.560 | 237.2 Da LogP -0.94 TPSA 137.9 | ✓ Ro5 | ✓ Clean |
N[C@H](CS[C@H](CC(=O)O)C(=O)O)C(=O)O
|
| ZINC22930761 | 0.559 | 349.3 Da LogP -3.43 TPSA 220.6 | 1 viol. | ✓ Clean |
NC(N)=NC[C@@H](O)C[C@@H](NCCN[C@@H](CC(=O)O)C(=…
|
| ZINC31394235 | 0.559 | 349.3 Da LogP -3.43 TPSA 220.6 | 1 viol. | ✓ Clean |
NC(N)=NC[C@H](O)C[C@H](NCCN[C@@H](CC(=O)O)C(=O)…
|
| ZINC1850353 | 0.556 | 206.1 Da LogP -0.86 TPSA 132.1 | ✓ Ro5 | ✓ Clean |
O=C(O)CC(O)(CC(=O)O)CC(=O)O
|
| ZINC19366195 | 0.538 | 260.3 Da LogP 0.67 TPSA 98.7 | ✓ Ro5 | ✓ Clean |
CCC[C@H](NCCN[C@@H](CCC)C(=O)O)C(=O)O
|
| ZINC19366197 | 0.538 | 260.3 Da LogP 0.67 TPSA 98.7 | ✓ Ro5 | ✓ Clean |
CCC[C@@H](NCCN[C@H](CCC)C(=O)O)C(=O)O
|
| ZINC2123927 | 0.538 | 204.2 Da LogP -1.62 TPSA 129.7 | ✓ Ro5 | ✓ Clean |
C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)O
|
| ZINC23480216 | 0.538 | 260.3 Da LogP 0.67 TPSA 98.7 | ✓ Ro5 | ✓ Clean |
CCC[C@H](NCCN[C@H](CCC)C(=O)O)C(=O)O
|
| ZINC393549 | 0.533 | 223.2 Da LogP 0.70 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
O=C(O)C[C@@H](NCc1ccccc1)C(=O)O
|
| ZINC9349 | 0.533 | 223.2 Da LogP 0.70 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
O=C(O)C[C@H](NCc1ccccc1)C(=O)O
|
| ZINC35465466 | 0.529 | 244.3 Da LogP 2.24 TPSA 91.7 | ✓ Ro5 | ✓ Clean |
O=C(O)CCCCCCCC(=O)CCC(=O)O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.