Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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Applied filters EC Number: 4.3.2.1

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EC Number: 4.3.2.1 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA3151 imidazole glycerol phosphate synthase subunit HisF hisF2, PA3151 AlphaFold DB model
4.3.2.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. GO:0016833Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. +25 total
No map 0.706 No Hit N/A —
2 PA5263 argininosuccinate lyase argH, PA5263 AlphaFold DB model
4.3.2.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004056Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. GO:0042450OBSOLETE. The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. +14 total
No map 0.635 Hit 65.3% 5.38e-15
3 PA5140 imidazole glycerol phosphate synthase subunit HisF hisF1, PA5140 AlphaFold DB model
4.3.2.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +14 total
No map 0.605 No Hit N/A —
4 PA3152 imidazole glycerol phosphate synthase subunit HisH hisH2, PA3152, hisH AlphaFold DB model
4.3.2.10 3.5.1.2
GO:0009382Complex that possesses imidazoleglycerol-phosphate synthase activity. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. +47 total
No map 0.22 No Hit N/A —
5 PA5142 imidazole glycerol phosphate synthase subunit HisH hisH1, PA5142 AlphaFold DB model
4.3.2.10 3.5.1.2
GO:0009382Complex that possesses imidazoleglycerol-phosphate synthase activity. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. +36 total
No map No pocket No Hit N/A —
Page 1 of 1 · 5 total proteins