Metabolic network

VK055_2481

phospho-N-acetylmuramoyl-pentapeptide- transferase

Back to protein
Network centrality 0.06601 top 96.4%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing chokepoint reaction in Peptidoglycan biosynthesis, no isoenzyme backup detected, more central than 96.4% of genes in this genome, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Peptidoglycan biosynthesis

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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EC
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN-11347

EC 2.7.8.13 · RXN-11347 · reversible · no isoenzyme backup

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanine di-trans,octa-cis-undecaprenyl phosphate
⇌
Und-PP-MurNAc-L-Ala-gamma-D-Glu-L-Lys-D-Ala UMP

RXN-11028

EC 2.7.8.13 · RXN-11028 · not reversible · no isoenzyme backup

UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala trans,octacis-decaprenyl phosphate
→
Dec-PP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala UMP

PHOSNACMURPENTATRANS-RXN

EC 2.7.8.13 · PHOSNACMURPENTATRANS-RXN · not reversible · no isoenzyme backup

Producing chokepoint
UDP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala di-trans,octa-cis-undecaprenyl phosphate
→
Und-PP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Ala UMP

RXN-8975

EC 2.7.8.13 · RXN-8975 · not reversible · no isoenzyme backup

Consuming chokepoint
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine di-trans,octa-cis-undecaprenyl phosphate
→
Und-PP-MurNAc-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala UMP

RXN-22610

EC 2.7.8.13 · RXN-22610 · not reversible · no isoenzyme backup

Producing & consuming chokepoint
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-lactate di-trans,octa-cis-undecaprenyl phosphate
→
Und-PP-MurNAc-L-Ala-gamma-D-Glu-meso-DAP-D-Ala-D-Lac UMP

Imported from KpATCC43816.sbml · 2026-07-09