Protein profile

VK055_4330

precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit

Genome: KpATCC43816

Gene: cbiE AIK82875.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUN1
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Amino acids 195
Annotations 4
Features 13
PDB binders 0
Druggability 0.132

Overview

Basic information about this protein and its source genome.

Accession
VK055_4330
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
cbiE AIK82875.1
Status
annotated
Amino acids
195
Structure source
AlphaFold + ColabFold
GO
GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
33.129
Localization
Cytoplasmic
ColabFold pLDDT
94.45

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.132
Structure A0A0H3GUN1
Pocket Pocket 3
P2Rank 0.704
Structure A0A0H3GUN1
Pocket Pocket 1
ColabFold model
FPocket 0.827 · Pocket 1
P2Rank 0.5 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 40 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 191 PANTHER PTHR43182 COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING)
1 95 Gene3D G3DSA:3.40.1010.10 -
1 95 InterPro IPR014777 Tetrapyrrole methylase, subdomain 1
96 195 Gene3D G3DSA:3.30.950.10 -
96 195 InterPro IPR014776 Tetrapyrrole methylase, subdomain 2
1 173 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases
1 173 InterPro IPR000878 Tetrapyrrole methylase
1 192 CDD cd11644 Precorrin-6Y-MT
1 192 InterPro IPR012818 Precorrin-6Y methyltransferase
1 192 SUPERFAMILY SSF53790 Tetrapyrrole methylase
1 192 InterPro IPR035996 Tetrapyrrole methylase superfamily
1 189 NCBIfam TIGR02467 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE
1 189 InterPro IPR012818 Precorrin-6Y methyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUN1
AlphaFold — — full sequence — Viewing
ColabFold VK055_4330
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.57 0.333
2 2.45 0.067