KEGG:map00860

Porphyrin metabolism

KpATCC43816 - Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

All pathways Protein ranking
Reactions 31
Proteins 26
Metabolites 68
Chokepoints 13

Pathway map

Reaction-to-metabolite flow reconstructed from the imported SBML participants.

Chokepoint reaction Metabolite ⇌ Reversible reaction Currency metabolites hidden
Computing layout…

Connected pathways

Other pathways in this genome that share reactions with this one.

MODEL Unassigned metabolic reactions 42 shared KEGG Purine metabolism 4 shared KEGG Nicotinate and nicotinamide metabolism 2 shared KEGG Terpenoid backbone biosynthesis 1 shared

Reaction table

Catalyzed reactions, mapped genes, and SBML substrates/products.

2.1.1.130-RXN

EC 2.1.1.130 · R03948 · 2.1.1.130-RXN · not reversible

S-adenosyl-L-methionine precorrin-2
→
S-adenosyl-L-homocysteine precorrin-3A H+
VK055_4337

2.1.1.131-RXN

EC 2.1.1.131 · R05180 · 2.1.1.131-RXN · not reversible

producing
S-adenosyl-L-methionine precorrin-3B
→
S-adenosyl-L-homocysteine precorrin-4 H+
VK055_4334

2.1.1.133-RXN

EC 2.1.1.133 · R05181 · 2.1.1.133-RXN · not reversible

consuming
S-adenosyl-L-methionine precorrin-4
→
S-adenosyl-L-homocysteine precorrin-5 H+
VK055_4332

4.1.1.81-RXN

EC 4.1.1.81 · R06530 · 4.1.1.81-RXN · reversible

L-threonine 3-O-phosphate H+
⇌
(R)-1-amino-2-propanol O-2-phosphate CO2
VK055_4301

6.3.1.10-RXN

EC 6.3.1.10 · R07302 · 6.3.1.10-RXN · not reversible

(R)-1-aminopropan-2-ol adenosylcobyrate ATP
→
adenosylcobinamide ADP H+ phosphate
VK055_4327

GLURS-RXN

EC 6.1.1.17 · R05578 · GLURS-RXN · not reversible

L-glutamate a tRNAglu ATP
→
an L-glutamyl-[tRNAGlu] AMP diphosphate
VK055_4762

GLUTRNAREDUCT-RXN

EC 1.2.1.70 · R04109 · GLUTRNAREDUCT-RXN · not reversible

both
an L-glutamyl-[tRNAGlu] H+ NADPH
→
(S)-4-amino-5-oxopentanoate a tRNAglu NADP+
VK055_0215

HEMEOSYN-RXN

EC 2.5.1.141 · R07411 · HEMEOSYN-RXN · not reversible

(2E,6E)-farnesyl diphosphate protoheme H2O
→
ferroheme o diphosphate
VK055_2164

HEMN-RXN

EC 1.3.98.3 · R06895 · HEMN-RXN · not reversible

consuming
S-adenosyl-L-methionine coproporphyrinogen III
→
5'-deoxyadenosine L-methionine protoporphyrinogen IX CO2
VK055_3298

R343-RXN

EC - · R05218 · R343-RXN · not reversible

a [reduced flavoprotein] cob(II)yrinate a,c-diamide-[corrinoid adenosyltranferase]
→
an [oxidized flavoprotein] cob(I)yrinate a,c-diamide-[corrinoid adenosyltranferase] H+
No mapped protein

R344-RXN

EC - · R05220 · R344-RXN · not reversible

cob(I)yrinate a,c-diamide-[corrinoid adenosyltranferase] ATP H+
→
a [corrinoid adenosyltransferase] adenosyl-cob(III)yrinate a,c-diamide triphosphate
VK055_1187 VK055_3976 VK055_4310

R345-RXN

EC 6.3.5.10 · R05225 · R345-RXN · not reversible

both
L-glutamine adenosyl-cob(III)yrinate a,c-diamide ATP H2O
→
L-glutamate adenosylcobyrate ADP H+ phosphate
VK055_4342

RXN-10642

EC 4.1.1.37 · R04972 · RXN-10642 · not reversible

consuming
uroporphyrinogen-I H+
→
coproporphyrinogen I CO2
VK055_3095

RXN-13403

EC 2.1.1.107 · R03194 · RXN-13403 · not reversible

S-adenosyl-L-methionine uroporphyrinogen-III
→
S-adenosyl-L-homocysteine precorrin-2 H+
VK055_3716 VK055_4401

RXN-14063

EC 2.7.1.156 · R06558 · RXN-14063 · not reversible

adenosylcobinamide GTP
→
adenosyl-cobinamide phosphate GDP H+
VK055_4343

RXN-14396

EC - · R03166 · RXN-14396 · not reversible

preuroporphyrinogen
→
uroporphyrinogen-I H2O
No mapped protein

RXN-6261

EC 6.3.1.10 · R06529 · RXN-6261 · not reversible

(R)-1-amino-2-propanol O-2-phosphate adenosylcobyrate ATP
→
adenosyl-cobinamide phosphate ADP H+ phosphate
VK055_4327

RXN-8770

EC 3.1.3.73 · R04594 · RXN-8770 · not reversible

consuming
adenosylcobalamin 5'-phosphate H2O
→
adenosylcobalamin phosphate
VK055_1862

UROGENIIISYN-RXN

EC 4.2.1.75 · R03165 · UROGENIIISYN-RXN · not reversible

preuroporphyrinogen
→
uroporphyrinogen-III H2O
No mapped protein